지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 116 - 123 (8page)
이용수
초록· 키워드
오류제보하기
Background:Pamidronate is a potent inhibitor of osteoclast-mediated bone resorption. Recently, the drug has been known to relieve bone pain. We hypothesized that direct epidural administration of pamidronate could have various advantages over oral administration with respect to dosage, side effects, and efficacy. Therefore, we evaluated the neuronal safety of epidurally-administered pamidronate.
Methods:Twenty-seven rats weighing 250-350 g were equally divided into 3 groups. Each group received an epidural administration with either 0.3 ml (3.75 mg) of pamidronate (group P), 0.3 ml of 40% alcohol (group A), or 0.3 ml of normal saline (group N). A Pinch-toe test, motor function evaluation, and histopathologic examination of the spinal cord to detect conditions such as chromatolysis, meningeal inflammation, and neuritis, were performed on the 2nd, 7th, and 21st day following administration of each drug.
Results:All rats in group A showed an abnormal response to the pinch-toe test and decreased motor function during the entire evaluation period. Abnormal histopathologic findings, including neuritis and meningeal inflammation were observed only in group A rats. Rats in group P, with the exception of 1, and group N showed no significant sensory/motor dysfunction over a 3-week observation period. No histopathologic changes were observed in groups P and N.
Conclusions:Direct epidural injection of pamidronate (about 12.5 mg/kg) showed no neurotoxic evidence in terms of sensory/motor function evaluation and histopathologic examination. (Korean J Pain 2010; 23: 116-123)
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Abildgaard N / 2000 / Biochemical markers of bone metabolism reflect osteoclastic and osteoblastic activity in multiple myeloma / Eur J Haematol 64 : 121 ~ 129
Bajrovi? F / 1998 / Extent of nociceptive dermatomes in adult rats is not primarily maintained by axonal competition / Exp Neurol 150 : 115 ~ 121
Benford HL / 2001 / Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro / Bone 28 : 465 ~ 473
Body JJ / 2003 / Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastases / Ann Oncol 14 : 1399 ~ 1405
Bonabello A / 2001 / Analgesic effect of bisphosphonates in mice / Pain 91 : 269 ~ 275
Bajrovi? F / 1998 / Extent of nociceptive dermatomes in adult rats is not primarily maintained by axonal competition / Exp Neurol 150 : 115 ~ 121
Benford HL / 2001 / Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro / Bone 28 : 465 ~ 473
Body JJ / 2003 / Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastases / Ann Oncol 14 : 1399 ~ 1405
Bonabello A / 2001 / Analgesic effect of bisphosphonates in mice / Pain 91 : 269 ~ 275
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