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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제10호
- 발행연도
- 2018.1
- 수록면
- 1,614 - 1,625 (12page)
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초록· 키워드
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Periodontitis, which is a severe inflammatory disease caused by endotoxins secreted from oral pathogens, destructs gingival tissue and alveolar bone. Curcuma xanthorrhiza, commonly called Java turmeric, has been shown to possess anti-bacterial and anti-inflammatory activities. The present study evaluated the inhibitory effect of C. xanthorrhiza supercritical extract (CXS) standardized with xanthorrhizol on lipopolysaccharide (LPS)-induced periodontitis in an animal model. LPS was topically injected into the periodontium of Sprague-Dawley rats to induce periodontitis and CXS (30 and 100 mg·kg-1·day-1) was orally administered after day 12. Histologically, CXS inhibited the collapse of gingival tissue by preventing cell infiltration. CXS significantly downregulated the expression of matrix metalloproteases (MMPs) and inflammation-related biomarkers, such as nuclear factor-kappa B (NF-κB) and interleukin-1 beta (IL-1β) in gingival tissue. CXS also improved bone remodeling by downregulating osteoclastic transcription factors, such as nuclear factor of activated T-cells c1 (NFATc1), tartrate-resistant acid phosphatase (TRAP), and cathepsin K. In addition, CXS upregulated osteoblast differentiation-related markers, alkaline phosphate (ALP) and collagen type I alpha (COLA1). Thus, CXS can ameliorate periodontitis by inhibiting inflammation and improving bone remodeling.
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참고문헌 (4)
참고문헌 신청
Jung-Eun Kim / 2008 / Antibacterial Characteristics of Curcuma xanthorrhiza Extract on Streptococcus mutans Biofilm / The Journal of Microbiology 46(2):228~232
김백일 / 2005 / Curcuma xanthorrhiza 추출물 및 함유 치약의 구취 억제 효과와 구강 유해균에 대한 선택적 항균 효과 / 대한구강보건학회지 29(2):222~237
서태근 / 2012 / Porphyromonas gingivalis-Derived Lipopolysaccharide-Mediated Activation of MAPK Signaling Regulates Inflammatory Response and Differentiation in Human Periodontal Ligament Fibroblasts / The Journal of Microbiology 50(2):311~319
고선일 / 2016 / Inhibitory Effect of Myricetin on Matrix Metalloproteinase Expression and Activity in Periodontal Inflammation / International Journal of Oral Biology 41(4):163~173
김백일 / 2005 / Curcuma xanthorrhiza 추출물 및 함유 치약의 구취 억제 효과와 구강 유해균에 대한 선택적 항균 효과 / 대한구강보건학회지 29(2):222~237
서태근 / 2012 / Porphyromonas gingivalis-Derived Lipopolysaccharide-Mediated Activation of MAPK Signaling Regulates Inflammatory Response and Differentiation in Human Periodontal Ligament Fibroblasts / The Journal of Microbiology 50(2):311~319
고선일 / 2016 / Inhibitory Effect of Myricetin on Matrix Metalloproteinase Expression and Activity in Periodontal Inflammation / International Journal of Oral Biology 41(4):163~173
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