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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제6호
- 발행연도
- 2018.1
- 수록면
- 902 - 908 (7page)
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초록· 키워드
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Optimization of the culture medium to maximize menaquinone-7 (MK-7) production by Bacillus subtilis strain KCTC 12392BP in static culture was carried out using statistical experimental methods, including one factor at a time, fractional factorial design, and response surface methodology (RSM). Maltose (carbon source), tryptone (nitrogen source), and glycerol (activator) were identified as the key medium components for MK-7 synthesis by the fractional factorial design, and were selected for statistical optimization by RSM. The statistical analysis indicated that, in the range that was studied, maltose, tryptone, and glycerol were all critical factors having profound effects on the production of MK-7, with their coefficients for linear and quadratic all significant at the p < 0.05 level. The established model was efficient and feasible, with a determination coefficient (R2) of 0.9419. The predicted concentrations of maltose, tryptone, and glycerol in the optimal medium were determined as 36.78, 62.76, and 58.90 g/l, respectively. In this optimized medium, the maximum yield of MK-7 reached a remarkably high level of 71.95 ± 1.00 μg/ml after 9 days of static fermentation, which further verified the practicability of this optimized strategy.
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참고문헌 (23)
참고문헌 신청
Stewart JD / 1939 / Prothrombin deficiency and the effects of vitamin K in obstructive jaundice and biliary fistula / Ann. Surg. 109:588~595
Tsukamoto Y / 2001 / Construction of a Bacillus subtilis (natto) with high productivity of vitamin $K_2$ (menaquinone-7) by analog resistance / Biosci. Biotechnol. Biochem. 65:2007~2015
Lamson DW / 2003 / The anticancer effects of vitamin K / Altern. Med. Rev. 8:303~318
Tsukamoto Y / 2004 / Studies on action of menaquinone-7 in regulation of bone metabolism and its preventive role of osteoporosis / Biofactors 22:5~19
Gast GCM / 2009 / A high menaquinone intake reduces the incidence of coronary heart disease / Nutr. Metab. Cardiovasc. Dis. 19:504~510
Tsukamoto Y / 2001 / Construction of a Bacillus subtilis (natto) with high productivity of vitamin
Lamson DW / 2003 / The anticancer effects of vitamin K / Altern. Med. Rev. 8:303~318
Tsukamoto Y / 2004 / Studies on action of menaquinone-7 in regulation of bone metabolism and its preventive role of osteoporosis / Biofactors 22:5~19
Gast GCM / 2009 / A high menaquinone intake reduces the incidence of coronary heart disease / Nutr. Metab. Cardiovasc. Dis. 19:504~510
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