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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제9호
- 발행연도
- 2015.1
- 수록면
- 1,485 - 1,492 (8page)
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Makgeolli is a traditional wine in Korea and has been traditionally believed to exhibit health benefits. However, the inhibitory effect of dealcoholized makgeolli (MK) on cancer has never been investigated scientifically. In this study, MK exhibited an anti-angiogenic effect by inhibiting tube formation in human umbilical vein endothelial cells, without cytotoxicity. Treatment with MK reduced the proliferation of AGS human gastric adenocarcinoma cells in a dose-dependent manner and increased the sub-G1 population. Next, we evaluated whether MK could induce apoptosis in AGS cells by using the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay or Annexin V method. Treatment with MK at 500 and 1,000 μg/ml increased the number of TUNEL-positive AGS cells. Under the same conditions, MK-treated (500 and 1,000 μg/ml) cells showed significant induction of early or late apoptosis, compared with untreated cells (no induction). In addition, MK also induced phosphatase and tensin homolog (PTEN) expression in AGS cells. However, p53 expression in AGS cells was not changed by MK treatment. Furthermore, MK at 500 mg/kg·d reduced the tumor size and volume in AGS tumor xenografts. Taken together, MK may be useful for the prevention of cancer cell growth.
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참고문헌 (21)
참고문헌 신청
Arumugam A / 2014 / Neem leaf extract inhibits mammary carcinogenesis by altering cell proliferation, apoptosis, and angiogenesis / Cancer Biol. Ther 15 : 26 ~ 34
Chen Q / 2010 / Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells / PLoS One 5 : e15288 ~
Chin-Hui Su / 2013 / Increase of Phosphatase and Tensin Homolog by Silymarin to Inhibit Human Pharynx Squamous Canc
Crane C / 2009 / Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impact
Ha J / 2014 / Determination of E,E-farnesol in makgeolli (rice wine) using dynamic headspace sampling and stir bar sorptive extraction coupled with gas chromatography-mass sp
Chen Q / 2010 / Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells / PLoS One 5 : e15288 ~
Chin-Hui Su / 2013 / Increase of Phosphatase and Tensin Homolog by Silymarin to Inhibit Human Pharynx Squamous Canc
Crane C / 2009 / Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impact
Ha J / 2014 / Determination of E,E-farnesol in makgeolli (rice wine) using dynamic headspace sampling and stir bar sorptive extraction coupled with gas chromatography-mass sp
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