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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제6호
- 발행연도
- 2010.1
- 수록면
- 988 - 994 (7page)
이용수
초록· 키워드
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The EtOAc fraction of Lespedeza cyrtobotrya showed mushroom tyrosinase inhibitory and radical scavenging activities. Four active compounds were isolated based on Sephadex LH-20 chromatography and HPLC, and the structures were elucidated, on the basis of their LC-MS and NMR spectral data, as 2-(2,4-dihydroxyphenyl)-6-hydroxybenzofuran (1), eriodictyol-7-O-glucopyranoside (2),haginin A (3), and dalbergioidin (4), respectively. Compound (1) showed mushroom tyrosinase inhibitory activity with an IC50 value of 5.2 μM and acted as a competitive inhibitor. Furthermore, 37.3 μM of compound 1 reduced 50% of the melanin content on human melanoma (MNT-1) cells. The radical scavenging activities of compounds 1,2, 3, and 4 were shown to have IC50 values of 11.0, 24.5,9.0, and 36.5 μM, respectively, in an ABTS system and IC50 values of 42.7, 36.0, 37.7, and 61.7 μM, respectively, in a DPPH system. The mushroom tyrosinase inhibitory activity of the EtOAc fraction of Lespedeza cyrtobotrya was contributed by compounds 1, 3, and 4, and its radical scavenging activity was contributed by compounds 1-4.
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참고문헌 (25)
참고문헌 신청
Abdel-Malek, Z. A / 2008 / The melanocortin 1 receptor and the UV response of human melanocytes - a shift in paradigm / Photochem. Photobiol 84 : 501 ~ 508
Baek, Seunghwa / 2008 / Inhibitory Effect of Dalbergioidin Isolated from the Trunk of Lespedezacyrtobotrya on Melanin Biosynthesis / Journal of Microbiology and Biotechnology
Duncan, C. L / 1968 / Effect of sodium nitrite, sodium chloride, and sodium nitrate on germination and outgrowth of anaerobic spores / Appl. Microbiol 16 : 406 ~ 411
Fitton, A / 1991 / Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders / Drugs 41 : 780 ~ 798
Garrett, R / 2005 / Biochemistry / Thomson Brooks/Cole : 421 ~ 432
Baek, Seunghwa / 2008 / Inhibitory Effect of Dalbergioidin Isolated from the Trunk of Lespedezacyrtobotrya on Melanin Biosynthesis / Journal of Microbiology and Biotechnology
Duncan, C. L / 1968 / Effect of sodium nitrite, sodium chloride, and sodium nitrate on germination and outgrowth of anaerobic spores / Appl. Microbiol 16 : 406 ~ 411
Fitton, A / 1991 / Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders / Drugs 41 : 780 ~ 798
Garrett, R / 2005 / Biochemistry / Thomson Brooks/Cole : 421 ~ 432
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