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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제11호
- 발행연도
- 2018.1
- 수록면
- 1,806 - 1,813 (8page)
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초록· 키워드
오류제보하기
A new sesquiterpene lactone dimer [1], together with five known compounds (2–6), was isolated from the flowers of Inula britannica. The structures of these compounds were established by extensive spectroscopic studies and chemical evidence. The inhibitory activities of these isolated compounds (1–6) against human neutrophil elastase (HNE) were also evaluated in vitro; compounds 1 and 6 exhibited significant inhibitory effects against HNE activity, with IC50 values of 8.2 and 10.4 μM, respectively, comparable to that of epigallocatechin gallate (EGCG; IC50 = 10.9 μM). In addition, compounds 3 and 5 exhibited moderate HNE inhibitory effects, with IC50 values of 21.9 and 42.5 μM, respectively. In contrast, compounds 2 and 4 exhibited no such activity (IC50 > 100 μM). The mechanism by which 1 and 3 inhibited HNE was noncompetitive inhibition, with inhibition constant (Ki) values of 8.0 and 22.8 μM, respectively.
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참고문헌 (26)
참고문헌 신청
Lin R / 1989 / Flora of China / Science Press :263~265
Bai N / 2005 / Antioxidative flavonoids from the flower of Inula Britannica / J. Food Lipids 12:141~149
Zhao YM / 2006 / Chemical constituents of plants from the genus Inula / Chem. Biodivers 3:371~384
Tang SA / 2014 / Anti-inflammatory terpenes from flowers of Inula japonica / Planta Med 80:583~589
이나경 / 2013 / Antimicrobial Effect of Inula britannica Flower Extract against Methicillin-resistant Staphylococcus aureus / 한국미생물·생명공학회지 41(3):335~340
Bai N / 2005 / Antioxidative flavonoids from the flower of Inula Britannica / J. Food Lipids 12:141~149
Zhao YM / 2006 / Chemical constituents of plants from the genus Inula / Chem. Biodivers 3:371~384
Tang SA / 2014 / Anti-inflammatory terpenes from flowers of Inula japonica / Planta Med 80:583~589
이나경 / 2013 / Antimicrobial Effect of Inula britannica Flower Extract against Methicillin-resistant Staphylococcus aureus / 한국미생물·생명공학회지 41(3):335~340
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