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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제5호
- 발행연도
- 2008.1
- 수록면
- 874 - 879 (6page)
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초록· 키워드
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Tyrosinase is a key enzyme for melanin biosynthesis, and hyperpigmentation disorders are associated with abnormal accumulation of melanin pigments, which can be reduced by treatment with depigmenting agents. The methanol extract of Lespedeza cyrtobotrya MIQ showed inhibitory activity against mushroom tyrosinase. The active compound was purified from the methanol extract of L. cyrtobotrya, followed by several chromatographic methods, and identified as dalbergioidin (DBG) by spectroscopic methods. The results showed that DBG exhibited tyrosinase inhibitory activity with an IC50 of 20 μM. The kinetic analysis of tyrosinase inhibition revealed that DBG acted as a noncompetitive inhibitor. In addition, DBG showed a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Furthermore, 27 μM DBG decreased more than 50% of melanin contents on the pigmentation using the immortalized mouse melanocyte, melan-a cell.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Ahn, S. J. / 2006 / Regulation of melanin synthesis by selenium-containing carbohydrates. Chem. Pharm / Bull 54 : 281 ~ 286
BAEK SEUNGHWA / 2006 / Idescarpin Isolated from the Fruits of Idesia polycarpa Inhibits Melanin Biosynthesis / Journal of Microbiology and Biotechnology 16 (5) : 667 ~ 672
Bennett, D. C. / 1987 / A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumor promoter for growth. Int / Cancer 39 : 414 ~ 418
Chun, H. J. / 2002 / Effect of quercetin on melanogenesis in Melan-a melanocyte cells. Kor / Pharmcogn 33 : 245 ~ 251
Chun, H. J. / 2002 / Inhibitory effects of butyl alcohol extract from Caesalpinia sappan L. on melanogenesis in Melan-a cells. Kor / Pharmcogn 33 : 130 ~ 136
BAEK SEUNGHWA / 2006 / Idescarpin Isolated from the Fruits of Idesia polycarpa Inhibits Melanin Biosynthesis / Journal of Microbiology and Biotechnology 16 (5) : 667 ~ 672
Bennett, D. C. / 1987 / A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumor promoter for growth. Int / Cancer 39 : 414 ~ 418
Chun, H. J. / 2002 / Effect of quercetin on melanogenesis in Melan-a melanocyte cells. Kor / Pharmcogn 33 : 245 ~ 251
Chun, H. J. / 2002 / Inhibitory effects of butyl alcohol extract from Caesalpinia sappan L. on melanogenesis in Melan-a cells. Kor / Pharmcogn 33 : 130 ~ 136
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