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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제5호
- 발행연도
- 2008.1
- 수록면
- 866 - 873 (8page)
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초록· 키워드
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2-Deoxystreptamine is a core aglycon that is vital to
backbone formation in various aminoglycosides. This core
structure can be modified to develop hybrid types of
aminoglycoside antibiotics. We obtained three genes
responsible for 2-deoxystreptamine production, neo7, neo6,
and neo5, which encode 2-deoxy-scyllo-inosose synthase, Lglutamine:
2-deoxy-scyllo-inosose aminotransferase, and
dehydrogenase, respectively, from the neomycin gene cluster.
These genes were cloned into pIBR25, a Streptomyces
expression vector, resulting in pNDOS. The recombinant
pNDOS was transformed into a non-aminoglycosideproducing
host, Streptomyces venezuelae YJ003, for
heterologous expression. Based on comparisons of the
retention time on LC-ESI/MS and ESI-MS data with
those of the 2-deoxystreptamine standard, a compound
produced by S. venezuelae YJ003/pNDOS was found to be
2-deoxystreptamine.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Hong, J. S. / 2004 / New olyvosyl derivatives of methymycin/ pikromycin from an engineered strain of Streptomyces venezuelae. FEMS Microbiol / Lett 238 : 392 ~ 399
Hong, Jay Sung / 2005 / The Role of a Second Protein (DesVIII) in Glycosylation for the Biosynthesis of Hybrid Macrolide Antibiotics in Streptomyces Venezuelae / Journal of M
Huang, F. / 2005 / The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: Characterization of an aminotransferase involved in the formation of 2- deoxystr
KWON, YOUNGJOO / 2006 / Studies on the Binding Affinity of Aminoglycoside Antibiotics to the HIV-1 Rev Responsive Element for Designing Potential Antiviral Agents / Journal o
Kharel, M. K. / 2004 / A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: Comparison with gentamicin biosynthetic gene cluster. Arch. Biochem / Bio
Hong, Jay Sung / 2005 / The Role of a Second Protein (DesVIII) in Glycosylation for the Biosynthesis of Hybrid Macrolide Antibiotics in Streptomyces Venezuelae / Journal of M
Huang, F. / 2005 / The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: Characterization of an aminotransferase involved in the formation of 2- deoxystr
KWON, YOUNGJOO / 2006 / Studies on the Binding Affinity of Aminoglycoside Antibiotics to the HIV-1 Rev Responsive Element for Designing Potential Antiviral Agents / Journal o
Kharel, M. K. / 2004 / A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: Comparison with gentamicin biosynthetic gene cluster. Arch. Biochem / Bio
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