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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제21권 제6호
- 발행연도
- 2011.1
- 수록면
- 613 - 616 (4page)
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초록· 키워드
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Streptomyces venezuelae YJ028, bearing a deletion of the entire biosynthetic gene cluster encoding the pikromycin polyketide synthases and desosamine biosynthetic enzymes,was used as a bioconversion system for combinatorial biosynthesis of glycosylated derivatives of tylosin. Two engineered deoxysugar biosynthetic pathways for the biosynthesis of TDP-3-O-demethyl-D-chalcose or TDP-Lrhamnose in conjunction with the glycosyltransferaseauxiliary protein pair DesVII/DesVIII were expressed in a S. venezuelae YJ028 mutant strain. Supplementation of each mutant strain capable of producing TDP-3-O-demethyl-D-chalcose or TDP-L-rhamnose with tylosin aglycone tylactone resulted in the production of the 3-O-demethyl-D-chalcose, D-quinovose, or L-rhamnose-glycosylated tylactone.
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참고문헌 (15)
참고문헌 신청
Borisova, S. A. / 1999 / Biosynthesis of desosamine: Construction of a new macrolide carrying a genetically designed sugar moiety / Org. Lett 1 : 133 ~ 136
Borisova, S. A. / 2006 / Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: Opportunities, limitations, and mechanistic hypotheses / Angew Chem.
Chu, D. T / 1999 / Recent progress in novel macrolides, quinolones, and 2-pyridones to overcome bacterial resistance / Med. Res. Rev 19 : 497 ~ 520
Corcoran, J. W / 1977 / Relationship of ribosomal binding and antibacterial properties of tylosin-type antibiotics / J. Antibiot. (Tokyo) 30 : 1012 ~ 1014
Hong, J. S. J / 2004 / New olivosyl derivatives of methymycin/pikromycin from an engineered strain of Streptomyces venezuelae / FEMS MICROBIOLOGY LETTERS 238 : 391 ~ 399
Borisova, S. A. / 2006 / Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: Opportunities, limitations, and mechanistic hypotheses / Angew Chem.
Chu, D. T / 1999 / Recent progress in novel macrolides, quinolones, and 2-pyridones to overcome bacterial resistance / Med. Res. Rev 19 : 497 ~ 520
Corcoran, J. W / 1977 / Relationship of ribosomal binding and antibacterial properties of tylosin-type antibiotics / J. Antibiot. (Tokyo) 30 : 1012 ~ 1014
Hong, J. S. J / 2004 / New olivosyl derivatives of methymycin/pikromycin from an engineered strain of Streptomyces venezuelae / FEMS MICROBIOLOGY LETTERS 238 : 391 ~ 399
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