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논문 기본 정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제15권 제2호
- 발행연도
- 2005.1
- 수록면
- 346 - 353 (8page)
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A 50-kb chromosome DNA region was isolatedfrom Streptomyces kanamyceticus by screening the fosmidgenomic library, using the 16S rRNA methylase gene (kmr)as a probe. Sequence analysis of this region revealed 42putative open reading frames (ORFs), which included biosyntheticgenes such as genes responsible for 2-deoxystreptamine (2-DOS) biosynthesis as well as genes for resistance and regulatoryfunction. Also, the kanamycin acetyltransferase gene (kac)was characterized by in vitro enzyme assay, which conferredE. coli BL21 (DE3) with 10, 50, and 80-times higher resistanceto kanamycin A, tobramycin, and amikacin, respectively, thanthe control strain had, thus strongly indicating that the isolatedgene cluster is very likely involved in kanamycin biosynthesis.This work provides a solid basis for further elucidation of thekanamycin biosynthesis pathway as well as the productivityimprovement and construction of new hybrid antibiotics.
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참고문헌 (26)
참고문헌 신청
A / 2003 / Aminoglycoside resistance resultingfrom tight drug binding to an altered aminoglycosideacetyltransferase : 1577 ~ 1583
A / 2004 / Biosynthesis ofdeoxyaminosugars in antibiotic-producing bacteria 64 : 7 ~ 15
Analysisof a kanamycin resistance gene / 1998 / from Streptomyceskanamyceticus and a mutant with increased aminoglycosideresistance : 231 ~ 239
Aoki / 2002 / kasT gene of Streptomyces kasugaensis M38-M1encodes a DNA-binding protein which binds to intergenicregion of kasU-kasJ in the kasugamycin biosynthesis geneclus
Arakawa / 2002 / Characterization of the early stage aminoshikimatepathway in the formation of 3-amino-5-hydroxybenzoic acid The RifN protein specifically converts kanosamine
A / 2004 / Biosynthesis ofdeoxyaminosugars in antibiotic-producing bacteria 64 : 7 ~ 15
Analysisof a kanamycin resistance gene / 1998 / from Streptomyceskanamyceticus and a mutant with increased aminoglycosideresistance : 231 ~ 239
Aoki / 2002 / kasT gene of Streptomyces kasugaensis M38-M1encodes a DNA-binding protein which binds to intergenicregion of kasU-kasJ in the kasugamycin biosynthesis geneclus
Arakawa / 2002 / Characterization of the early stage aminoshikimatepathway in the formation of 3-amino-5-hydroxybenzoic acid The RifN protein specifically converts kanosamine
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