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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제5호
- 발행연도
- 2019.1
- 수록면
- 667 - 686 (20page)
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Streptomyces are attractive microbial cell factories that have industrial capability to produce a wide array of bioactive secondary metabolites. However, the genetic potential of the Streptomyces species has not been fully utilized because most of their secondary metabolite biosynthetic gene clusters (SM-BGCs) are silent under laboratory culture conditions. In an effort to activate SM-BGCs encoded in Streptomyces genomes, synthetic biology has emerged as a robust strategy to understand, design, and engineer the biosynthetic capability of Streptomyces secondary metabolites. In this regard, diverse synthetic biology tools have been developed for Streptomyces species with technical advances in DNA synthesis, sequencing, and editing. Here, we review recent progress in the development of synthetic biology tools for the production of novel secondary metabolites in Streptomyces, including genomic elements and genome engineering tools for Streptomyces, the heterologous gene expression strategy of designed biosynthetic gene clusters in the Streptomyces chassis strain, and future directions to expand diversity of novel secondary metabolites.
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참고문헌 (140)
참고문헌 신청
Ohnishi Y / 2008 / Genome sequence of the streptomycinproducing microorganism Streptomyces griseus IFO 13350 / J. Bacteriol 190:4050~4060
Khan ST / 2011 / Streptomyces associated with a marine sponge Haliclona sp,; biosynthetic genes for secondary metabolites and products / Environ. Microbiol 13:391~403
Onaka H. / 2017 / Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetes / J. Antibiot. (Tokyo) 70:865~870
Lim FY / 2012 / Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi / Methods Enzymol 517:303~324
Medema MH / 2011 / The future of industrial antibiotic production : from random mutagenesis to synthetic biology / Bioeng. Bugs 2:230~233
Khan ST / 2011 / Streptomyces associated with a marine sponge Haliclona sp,; biosynthetic genes for secondary metabolites and products / Environ. Microbiol 13:391~403
Onaka H. / 2017 / Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetes / J. Antibiot. (Tokyo) 70:865~870
Lim FY / 2012 / Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi / Methods Enzymol 517:303~324
Medema MH / 2011 / The future of industrial antibiotic production : from random mutagenesis to synthetic biology / Bioeng. Bugs 2:230~233
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