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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제2호
- 발행연도
- 2008.1
- 수록면
- 377 - 382 (6page)
이용수
초록· 키워드
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Interleukin-2 plays a significant role in T cell proliferation.
Here, we report the role of IL-2 in angiogenesis. IL-2 increased the ROS level and phosphorylation of Akt in human umbilical vein endothelial cells (HUVECs). IL-2 increased angiogenesis in an animal model and tube formation in HUVECs. The effect of IL-2 on angiogenesis and tube formation was mediated by ROS and Akt. This is the first report that IL-2 promotes angiogenesis.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Ariel, A. / 2001 / Cell surface-expressed moesin-like receptor regulates T cell interactions with tissue components and binds an adhesion-modulating IL-2 peptide generated by
Chen, C. J. / 2004 / The cell-cell adhesion molecule carcinoembryonic antigen-related cellular adhesion molecule 1 inhibits IL-2 production and proliferation in human T cells
Fung, M. M. / 2003 / IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells / Cell Signal 15 : 625 ~ 636
Healy, A. M. / 2006 / PKCtheta- deficient mice are protected from Th1-dependent antigeninduced arthritis / Immunol 177 : 1886 ~ 1893
Kawauchi, K. / 2005 / IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, hea
Chen, C. J. / 2004 / The cell-cell adhesion molecule carcinoembryonic antigen-related cellular adhesion molecule 1 inhibits IL-2 production and proliferation in human T cells
Fung, M. M. / 2003 / IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells / Cell Signal 15 : 625 ~ 636
Healy, A. M. / 2006 / PKCtheta- deficient mice are protected from Th1-dependent antigeninduced arthritis / Immunol 177 : 1886 ~ 1893
Kawauchi, K. / 2005 / IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, hea
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