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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제8호
- 발행연도
- 2018.1
- 수록면
- 1,332 - 1,338 (7page)
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초록· 키워드
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In the course of studies to discover natural products with anti-angiogenic properties, two cyclic octapeptides, octaminomycins A (1) and B (2), were isolated from the cultures of Streptomyces sp. RK85-270. Octaminomycins suppressed the vascular endothelial growth factor (VEGF)-induced proliferation, adhesion, tube formation, migration, and invasion of HUVECs. Anti-angiogenic activity was futher confirmed in vivo by the chicken chorioallantoic membrane assay. We also identified that 1 and 2 inhibited the phosphorylation of VEGF receptor 2, AKT, and ERK1/2 and the expression and activities of MMP-2 and MMP-9. These results suggest that 1 and 2 may serve as potential scaffolds for the development of therapeutic agents to angiogenesis-dependent diseases.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Ne wman DJ / 2016 / Natural products as sources of new drugs from 1981 to 2014 / J. Nat. Prod. 79:629~661
Cragg GM / 2013 / Natural products: a continuing source of novel drug leads / Biochim. Biophys. Acta 1830:3670~3695
Clardy J / 2006 / New antibiotics from bacterial natural products / Nat. Biotechnol. 24:1541~1550
Genilloud O / 2011 / Current approaches to exploit actinomycetes as a source of novel natural products / J. Ind. Microbiol. Biotechnol. 38:375~389
Nett M / 2009 / Genomic basis for natural product biosynthetic diversity in the actinomycetes / Nat. Prod. Rep. 26:1362~1384
Cragg GM / 2013 / Natural products: a continuing source of novel drug leads / Biochim. Biophys. Acta 1830:3670~3695
Clardy J / 2006 / New antibiotics from bacterial natural products / Nat. Biotechnol. 24:1541~1550
Genilloud O / 2011 / Current approaches to exploit actinomycetes as a source of novel natural products / J. Ind. Microbiol. Biotechnol. 38:375~389
Nett M / 2009 / Genomic basis for natural product biosynthetic diversity in the actinomycetes / Nat. Prod. Rep. 26:1362~1384
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