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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 343 - 352 (10page)
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초록· 키워드
오류제보하기
Frankincense, the gum resin derived from Boswellia species, is complex mixtures composed of about 5~9% highly aromatic essential oil, 65~85% alcohol-soluble resins, and the remaining water-soluble gums. The antiinflammatory properties of frankincense, alcohole-soluble resins, are well-recognized, but the question of whether aromatic essential oil also plays a role in the allergic asthma remains unanswered. This study was performed to evaluate anti-inflammatory effects of Boswellia sacra essential oil (BSEO) on ovalbumin (OVA)-induced asthma mouse model. BALB/c mice after intraperitoneal OVA sensitization were challenged with intratracheal OVA. One experimental group was inhaled with 0.3% BSEO for the later 8 weeks. BALB/c mice were sensitized and challenged with OVA and developed airway eosinophilia, mucus hypersecretion, and airway hyperresponsiveness. In contrast, the BSEO treated mice had reduced a number of eosinophils among BALF cells, goblet cell hyperplasia, and airway hyperresponsiveness. Cytokine analysis of BALF revealed that BSEO caused an increase in Th1 cytokine (interferon-γ (IFN-γ)) and a decrease in Th2 cytokines (interleukin-4 (IL-4), IL-5 and IL-13) levels. In addition, the OVA-specific serum IgE and eotaxin levels
were also reduced. In mice inhaled BSEO, CD4+, CD3+/CCR3+, and B220+/CD23+ mediastinal lymph nodes
cells were also decreased. These results suggest that inhaled BSEO as a immunomodulator in Th1/Th2 mediated asthma may have therapeutic potential for the treatment in allergic airway inflammation by a simple, cost-effective way.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Abe, S. / 2003 / Suppression of tumor necrosis factor-alpha-induced neutrophil adherence responses by essential oils / Med. Inflamm 12 : 323 ~ 328
Aronica, M. A. / 2004 / Recall helper T cell response: T helper 1 cell-resistant allergic susceptibility without biasing uncommitted CD4 T cells / Am. J. Respir. Crit. Care M
Barnes, P. J. / 1999 / Therapeutic strategy for allergic disease / Nature : B31 ~ 38
Barnes, P. J. 2000. Endogenous inhibitor / 2000 / Endogenous inhibitory mechanisms in asthma / Am. J. Respir. Crit. Care Med : S176 ~ 181
Barnes. P. J. / 1999 / Effect of bbb2-agonist on inflammatory cells / Barnes. P. J : 10 ~ 17
Aronica, M. A. / 2004 / Recall helper T cell response: T helper 1 cell-resistant allergic susceptibility without biasing uncommitted CD4 T cells / Am. J. Respir. Crit. Care M
Barnes, P. J. / 1999 / Therapeutic strategy for allergic disease / Nature : B31 ~ 38
Barnes, P. J. 2000. Endogenous inhibitor / 2000 / Endogenous inhibitory mechanisms in asthma / Am. J. Respir. Crit. Care Med : S176 ~ 181
Barnes. P. J. / 1999 / Effect of bbb2-agonist on inflammatory cells / Barnes. P. J : 10 ~ 17
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