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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 721 - 730 (10page)
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초록· 키워드
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Asthma is characterized by airway inflammation induced by immune dysfunction to inhaled antigens.
Although respiratory viral infections are the most common cause of asthma exacerbation, immunologic mechanisms underlying virus-associated asthma exacerbation are controversial. Clinical evidence indicates that nitric oxide (NO) levels in exhaled air are increased in exacerbated asthma patients compared to stable patients. Here, we evaluated the immunologic mechanisms and the role of NO synthases (NOSs) in the development of virus-associated asthma exacerbation.
A murine model of virus-associated asthma exacerbation was established using intranasal challenge with ovalbumin (OVA) plus dsRNA for 4weeks in mice sensitized with OVA plus dsRNA. Lung infiltration of inflammatory cells, especially neutrophils,was increased by repeated challenge with OVA plus dsRNA, as compared to OVA alone. The neutrophilic inflammation enhanced by dsRNA was partly abolished in the absence of IFN-gamma or IL-17 gene expression, whereas unaffected in the absence of IL-13. In terms of the roles of NOSs, dsRNA-enhanced neutrophilic inflammation was significantly decreased in inducible NOS (iNOS)-deficient mice compared to wild type controls; in addition, this phenotype was inhibited by treatment with a non-specific NOS inhibitor (L-NAME) or an specific inhibitor (1400 W), but not with a specific endothelial NOS inhibitor (AP-CAV peptide). Taken together, these findings suggest that iNOS pathway is important in the development of virus-associated exacerbation of neutrophilic inflammation,which is dependent on both Th1 and Th17 cell responses.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Alexopoulou L / 2001 / Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 / Nature 413 : 732 ~ 738
Annunziato F / 2007 / Phenotypic and functional features of human Th17 cells / J Exp Med 204 : 1849 ~ 1861
Bateman ED / 2008 / Global strategy for asthma management and prevention : GINA executive summary / Eur Respir J 31 : 143 ~ 178
Beasley R / 2000 / Prevalence and etiology of asthma / J Allergy Clin Immunol 105 : S466 ~ S472
Boehm U / 1997 / Cellular responses to interferon-gamma / Annu Rev Immunol 15 : 749 ~ 795
Annunziato F / 2007 / Phenotypic and functional features of human Th17 cells / J Exp Med 204 : 1849 ~ 1861
Bateman ED / 2008 / Global strategy for asthma management and prevention : GINA executive summary / Eur Respir J 31 : 143 ~ 178
Beasley R / 2000 / Prevalence and etiology of asthma / J Allergy Clin Immunol 105 : S466 ~ S472
Boehm U / 1997 / Cellular responses to interferon-gamma / Annu Rev Immunol 15 : 749 ~ 795
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