지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 321 - 328 (8page)
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초록· 키워드
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The number of patient with allergic asthma and atopy have increased in the cities of Korea steadily. In order to elucidate the primary factor, we investigated whether the house dust particles collected from an apartment of the middle classes has promoting effects of allergen-related airway inflammation and airway hyperresponsiveness. Mice were treated with 0.1 mL of 1 ㎎/mL of house dust particles suspension by intratracheal instillation once weekly for 10 weeks combined with ovalalbumin (OVA) sensitization. Intratracheal instillation of house dust particles and OVA sensitization caused an increase in the level of serum L-lactate dehydrogenase (LDH), immunoglobulun-E (IgE) and histamine, and an elevation in respiratory resistance. It also enhanced infiltration of eosinophils in the bronchoalveolar lavage fluid (BALF) of mice, IgE and eotaxin expression in blood, and T helper type 2 cell derived cytokine levels such as of interleukin (IL)-4, IL-13 and IL-5 in the BALF. However, it did not influence T helper type 1 cytokine such as interferon-gamma in the BALF. These results indicate that house dust particles elevate allergen-related airway inflammation and airway hyperresponsiveness in mice and may play an important role in the aggravation of asthma and atopy in Korea.
목차
Abstract
1. 서론
2. 연구 방법
3. 결과 및 토론
4. 결론
참고문헌
참고문헌 (24)
참고문헌 신청
Colt, J.S. , 2008 , Household vacuum cleaners vs. the high-volume surface sampler for collection of carpet dust samplers in epidermiologic studies of children , Environ. Health 7 : 7 ~
Finotto, S. , 2001 , Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression , J. Exp. Med 193 : 1247 ~ 1260
Hammond, H. , 2004 , Differential capacity of CD8+ alpha or CD8- alpha dendritic cell subsets to prime for eosinophilic airway inflammation in the Thelper type 2-prone milieu of the lung , Allergy 12 : 1834 ~ 1840
조완근 , 2003 , Photocatalytic Oxidation of Indoor Air Volatile Organic Compounds (VOCs) in ppb Level , Journal of Korean Society for Atmospheric Environment 19 (E4) : 157 ~ 168
Kim, B.J. , 2006 , Cause of death in COPD patients of a referral hospital , Tuberc. Respir. Dis 60 : 510 ~ 515
Finotto, S. , 2001 , Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression , J. Exp. Med 193 : 1247 ~ 1260
Hammond, H. , 2004 , Differential capacity of CD8+ alpha or CD8- alpha dendritic cell subsets to prime for eosinophilic airway inflammation in the Thelper type 2-prone milieu of the lung , Allergy 12 : 1834 ~ 1840
조완근 , 2003 , Photocatalytic Oxidation of Indoor Air Volatile Organic Compounds (VOCs) in ppb Level , Journal of Korean Society for Atmospheric Environment 19 (E4) : 157 ~ 168
Kim, B.J. , 2006 , Cause of death in COPD patients of a referral hospital , Tuberc. Respir. Dis 60 : 510 ~ 515
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UCI(KEPA) : I410-ECN-0101-2009-539-014843164