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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.10
- 수록면
- 813 - 821 (9page)
- DOI
- 10.17495/easdl.2015.10.25.5.813
이용수
초록· 키워드
오류제보하기
Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. The purpose of the present study was to evaluate the anti-inflammatory and anti-asthma effects of Adenophora triphylla var. japonica extracts. We investigated the molecular mechanism underlying the effects of 80% ethanol extracts (AE) of A. triphylla on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. AE treatment inhibited pro-inflammatory cytokines such as TNF-α and IL-6 as well as nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. In particular, NO and pro-inflammatory cytokine production was suppressed more effectively by aerial parts (AE-A) than roots (AE-R) of A. triphylla. Quantitative RTPCR assay showed that AE reduced mRNA levels of iNOS and COX-2. We also evaluated the anti-asthmatic effects of AE-A in an ovalbumin (OVA)-induced BALB/c mouse model. AE-A supplementation significantly reduced the amounts of airway eosinophils, IL-4 and IL-13 levels in BALF, and IgE levels in serum as compared with untreated, OVA-induced mice. These results suggest that AE-A can be considered as a therapeutic agent to potentially relieve asthma.
목차
ABSTRACT
서론
재료 및 방법
결과
고찰
결론
REFERENCES
참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)] - Ahn EK / 2013 / Lupenone isolated from Adenophora triphylla var. japonica extract inhibits adipogenic differen- tiation through the downregulation of PPARγ in 3T3-L1 cells / Phytother Res 27 (5) : 761 ~ 766
[학술지(정기간행물)] - Asano N / 2000 / Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica(Campanulaceae) / Phy-tochemistry 53 (3) : 379 ~ 382
[학술지(정기간행물)] - Baiz N / 2012 / Is the asthma epidemic still ascending? / Clinics in Chest Medicine 33 : 419 ~ 429
[학술지(정기간행물)] - Brennan FM / 1998 / Role of proinfla-mmatory cytokines in rheumatoid arthritis / Springer Semin Immunopathol 20 : 133 ~ 147
[학술지(정기간행물)] - Brugiolo AS / 2011 / Effects of aqueous extract of Echinodorus grandiflorus on the immune response in ovalbumin-induced pulmonary allergy / Ann Allergy Asthma Immunol 106 : 481 ~ 488
[학술지(정기간행물)] - Asano N / 2000 / Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica(Campanulaceae) / Phy-tochemistry 53 (3) : 379 ~ 382
[학술지(정기간행물)] - Baiz N / 2012 / Is the asthma epidemic still ascending? / Clinics in Chest Medicine 33 : 419 ~ 429
[학술지(정기간행물)] - Brennan FM / 1998 / Role of proinfla-mmatory cytokines in rheumatoid arthritis / Springer Semin Immunopathol 20 : 133 ~ 147
[학술지(정기간행물)] - Brugiolo AS / 2011 / Effects of aqueous extract of Echinodorus grandiflorus on the immune response in ovalbumin-induced pulmonary allergy / Ann Allergy Asthma Immunol 106 : 481 ~ 488
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UCI(KEPA) : I410-ECN-0101-2016-594-002087261