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대한생화학·분자생물학회 Experimental and Molecular Medicine Experimental and Molecular Medicine 제49권
발행연도
2017.1
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1 - 8 (8page)

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Skin wound closure occurs when keratinocytes migrate from the edge of the wound and re-epithelialize the epidermis. Their migration takes place primarily before any vascularization is established, that is, under hypoxia, but relatively little is known regarding the factors that stimulate this migration. Hypoxia and an acidic environment are well-established stimuli for cancer cell migration. The carbonic anhydrases (CAs) contribute to tumor cell migration by generating an acidic environment through the conversion of carbon dioxide to bicarbonate and a proton. On this basis, we explored the possible role of CAs in tissue regeneration using mouse skin wound models. We show that the expression of mRNAs encoding CA isoforms IV and IX are increased (~25 × and 4 × , respectively) during the wound hypoxic period (days 2–5) and that cells expressing CAs form a bandlike structure beneath the migrating epidermis. RNA-Seq analysis suggested that the CA IV-specific signal in the wound is mainly derived from neutrophils. Due to the high level of induction of CA IV in the wound, we treated skin wounds locally with recombinant human CA IV enzyme. Recombinant CA IV significantly accelerated wound re-epithelialization. Thus, CA IV could contribute to wound healing by providing an acidic environment in which the migrating epidermis and neutrophils can survive and may offer novel opportunities to accelerate wound healing under compromised conditions.

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참고문헌 (1)

참고문헌 신청
Woodley DT / 2015 / Keratinocyte migration and a hypothetical new role for extracellular heat shock protein 90 alpha in orchestrating skin wound healing / Adv Wound Care 4 : 203 ~ 212 | 2. [학술지(정기간행물)] - Martin P / 2015 / Cellular and molecular mechanisms of repair in acute and chronic wound healing / Br J Dermatol 173 : 370 ~ 378 | 3. [학술지(정기간행물)] - Benej M / 2014 / Carbonic anhydrase IX : regulation and role in cancer / Subcell Biochem 75 : 199 ~ 219 | 4. [학술지(정기간행물)] - Pastorekova S / 1997 / Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts / Gastroenterology 112 : 398 ~ 408 | 5. [학술지(정기간행물)] - Waheed A / 2014 / Membrane associated carbonic anhydrase IV(CA IV) : a personal and historical perspective / Subcell Biochem 75 : 157 ~ 179 | 6. [학술지(정기간행물)] - Hilvo M / 2008 / Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV / Curr Pharm Des 14 : 672 ~ 678 | 7. [학술지(정기간행물)] - Aspatwar A / 2013 / An update on carbonic anhydraserelated proteins VIII, X and XI / J Enzyme Inhib Med Chem 28 : 1129 ~ 1142 | 8. [학술지(정기간행물)] - Ivanov S / 2001 / Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer / Am J Pathol 158 : 905 ~ 919 | 9. [학술지(정기간행물)] - Järvinen TA / 2007 / Molecular changes in the vasculature of injured tissues / Am J Pathol 171 : 702 ~ 711 | 10. [학술지(정기간행물)] - Livak KJ / 2001 / Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T))method / Methods 25 : 402 ~ 408 | 11. [학술지(정기간행물)] - Waheed A / 1997 / Human carbonic anhydrase IV : in vitro activation and purification of disulfide-bonded enzyme following expression in Escherichia coli / Protein Expr Purif 9 : 279 ~ 287 | 12. [학술지(정기간행물)] - Davidson JM / 2013 / Splinting strategies to overcome confounding wound contraction in experimental animal models / Adv Wound Care 2 : 142 ~ 148 | 13. [학술지(정기간행물)] - Blanc-Brude OP / 2002 / Inhibitor of apoptosis protein survivin regulates vascular injury / Nat Med 8 : 987 ~ 994 | 14. [학술지(정기간행물)] - Linsley PS / 2014 / Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis / PLoS ONE 9 : e109760 ~ | 15. [학술지(정기간행물)] - Jones M / 2014 / RNA-seq analysis of host and viral gene expression highlights interaction between varicella zoster virus and keratinocyte differentiation / PLoS Pathog 10 : e1003896 ~ | 16. [학술지(정기간행물)] - Uhlen M / 2015 / Proteomics. Tissue-based map of the human proteome / Science 347 : 1260419 ~ | 17. [학술지(정기간행물)] - Langmead B / 2009 / Ultrafast and memoryefficient alignment of short DNA sequences to the human genome / Genome Biol 10 : R25 ~ | 18. [학술지(정기간행물)] - Trapnell C / 2009 / TopHat : discovering splice junctions with RNA-Seq / Bioinformatics 25 : 1105 ~ 1111 | 19. [학술지(정기간행물)] - Trapnell C / 2010 / Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation / Nat Biotechnol 28 : 511 ~ 515 | 20. [학술지(정기간행물)] - May U / 2015 / Resistance of R-Ras knockout mice to skin tumour induction / Sci Rep 5 : 11663 ~ | 21. [학술지(정기간행물)] - Uusitalo-Jarvinen H / 2007 / Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis / Arterioscler Thromb Vasc Biol 27 : 1456 ~ 1462 | 22. [학술지(정기간행물)] - Mi H / 2013 / Large-scale gene function analysis with the PANTHER classification system / Nat Protoc 8 : 1551 ~ 1566 | 23. [학술지(정기간행물)] - Vähätupa M / 2016 / Lack of R-Ras leads to increased vascular permeability in ischemic retinopathy / Invest Ophthalmol Vis Sci 57 : 4898 ~ 4909 | 24. [학술지(정기간행물)] - Järvinen TA / 2010 / Target-seeking antifibrotic compound enhances wound healing and suppresses scar formation in mice / Proc Natl Acad Sci USA 107 : 21671 ~ 21676 | 25. [학술지(정기간행물)] - Pastorekova S / 2006 / Tumor-associated carbonic anhydrases and their clinical significance / Adv Clin Chem 42 : 167 ~ 216 | 26. [학술지(정기간행물)] - Shin HJ / 2011 / Carbonic anhydrase IX(CA9)modulates tumor-associated cell migration and invasion / J Cell Sci 124 : 1077 ~ 1087 | 27. [학술지(정기간행물)] - Svastova E / 2012 / Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain / J Biol Chem 287 : 3392 ~ 3402 | 28. [학술지(정기간행물)] - Niemela AM / 2007 / Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer / Cancer Epidemiol Biomarkers Prev 16 : 1760 ~ 1766 | 29. [학술지(정기간행물)] - Vietri Rudan M / 2015 / Genetic tailors : CTCF and cohesin shape the genome during evolution / Trends Genet 31 : 651 ~ 660 | 30. [학술지(정기간행물)] - Wang L / 2013 / Epidermal growth factor(EGF)-induced corneal epithelial wound healing through nuclear factor kappaB subtype-regulated CCCTC binding factor(CTCF)activation / J Biol Chem 288 : 24363 ~ 24371 | 31. [학술지(정기간행물)] - Hui P / 1995 / Isolation and functional characterization of the human gene encoding the myeloid zinc finger protein MZF-1 / Biochemistry 34 : 16493 ~ 16502 | 32. [학술지(정기간행물)] - Eguchi T / 2015 / Role and regulation of myeloid zinc finger protein 1 in cancer / J Cell Biochem 116 : 2146 ~ 2154 | 33. [학술지(정기간행물)] - Sevilla LM / 2015 / Glucocorticoid receptor and Klf4 co-regulate anti-inflammatory genes in keratinocytes / Mol Cell Endocrinol 412 : 281 ~ 289 | 34. [학술지(정기간행물)] - Kaushik DK / 2010 / Kruppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation / J Neuroinflammation 7 : 68 ~ | 35. [학술지(정기간행물)] - Liu J / 2015 / Honokiol downregulates Kruppel-like factor 4 expression, attenuates inflammation, and reduces histopathology after spinal cord injury in rats / Spine 40 : 363 ~ 368 | 36. [학술지(정기간행물)] - Ou L / 2015 / Kruppel-like factor KLF4 facilitates cutaneous wound healing by promoting fibrocyte generation from myeloid-derived suppressor cells / J Invest Dermatol 135 : 1425 ~ 1434 | 37. [학술지(정기간행물)] - Li J / 2012 / Expression of Kruppel-like factor KLF4 in mouse hair follicle stem cells contributes to cutaneous wound healing / PLoS ONE 7 : e39663 ~ | 38. [학술지(정기간행물)] - Grguric-Smith LM / 2015 / Neutropenia exacerbates infection by Acinetobacter baumannii clinical isolates in a murine wound model / Front Microbiol 6 : 1134 ~ | 39. [학술지(정기간행물)] - Parkos CA / 2016 / Neutrophil-epithelial interactions : a double-edged sword / Am J Pathol 186 : 1404 ~ 1416 | 40. [학술지(정기간행물)] - Fadini GP / 2016 / NETosis delays diabetic wound healing in mice and humans / Diabetes 65 : 1061 ~ 1071 | 41. [학술지(정기간행물)] - Horckmans M / 2017 / Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype / Eur Heart J 38 : 187 ~ 197 | 42. [학술지(정기간행물)] - Martinez D / 2006 / Extracellular acidosis induces neutrophil activation by a mechanism dependent on activation of phosphatidylinositol 3-kinase/Akt and ERK pathways / J Immunol 176 : 1163 ~ 1171 | 43. [학술지(정기간행물)] - Trevani AS / 1999 / Extracellular acidification induces human neutrophil activation / J Immunol 162 : 4849 ~ 4857 | 44. [학술지(정기간행물)] - Santi A / 2013 / The effects of CA IX catalysis products within tumor microenvironment / Cell Commun Signal 11 : 81 ~ | 45. [학술지(정기간행물)] - Ishii G / 2005 / In vivo and in vitro characterization of human fibroblasts recruited selectively into human cancer stroma / Int J Cancer 117 : 212 ~ 220 | 46. [학술지(정기간행물)] - Duscher D / 2015 / Fibroblast-specific deletion of hypoxia inducible factor-1 critically impairs murine cutaneous neovascularization and wound healing / Plast Reconstr Surg 136 : 1004 ~ 1013 | 47. [학술지(정기간행물)] - Wandernoth PM / 2015 / Normal fertility requires the expression of carbonic anhydrases II and IV in sperm / J Biol Chem 290 : 29202 ~ 29216 google schola

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