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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 240 - 249 (10page)
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초록· 키워드
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Transduction of cytokine gene into tumor cells is a promising method of tumor therapy, but the value is limited by accompanying side effects. To focus antitumor immune response to tumor antigen- specific CTL, we developed an antitumor vaccine by transfecting modified IL-2 gene in a membrane-bound form (mbIL-2) into B16F10 melanoma cells. The mbIL-2 clone showed reduced tumorigenicity and metastatic ability, and inhibited metastasis and prolonged the survival of mice against B16F10 cells. The inhibition of B16F10 metastasis by mbIL-2 was accompanied by the increment of CD8+ T cells. The metastasis of mbIL-2 clone was significantly increased in the CD8+ T cell-depleted mice, but not in CD4+ T cell depleted mice. Spleen cells immunized with the mbIL-2 clone showed higher CTL activity towards B16F10 cells than those immunized with control cells. The size of CD8+ T cell population in the lung of mice injected with the mbIL-2 clone was markedly greater than that of mice injected with B16F10 cells, but there was no detectible change in CD4+ and CD8+ T cell populations of lymph nodes and spleen. These results suggest that when the mbIL-2 clone is introduced into the blood stream, it migrates mainly to lung and activates CD8+ T cells in situ, possibly by direct priming. Such a tumor vaccine may ameliorate the toxic side effects encountered with conventional cytokine gene therapy.
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참고문헌 (29)
참고문헌 신청
/ / Tumour immunotherapy using an adenoviralvector expressing a membrane-bound mutant of murine TNFalpha : 1181 ~ 8
/ / Vaccination with irradiated tumor cells engineered to secretemurine granulocyte-macrophage colony-stimulating factor stimulatespotent dra (ff g) : 3539 ~ 43
/ / a novel member of the TNF family thatforms a heteromeric complex with lymphotoxin on the cellsurface : 847 ~ 56
/ / invivo interleukin 2-induced activation of lymphokine-activatedkiller cells and tumor cytotoxic T-cells in cervical lymphnodes of patie
/ 1986 / Clinical effects and toxicityof interleukin-2 in patients with cancer : 2764 ~ 72
/ / Vaccination with irradiated tumor cells engineered to secretemurine granulocyte-macrophage colony-stimulating factor stimulatespotent dra (ff g) : 3539 ~ 43
/ / a novel member of the TNF family thatforms a heteromeric complex with lymphotoxin on the cellsurface : 847 ~ 56
/ / invivo interleukin 2-induced activation of lymphokine-activatedkiller cells and tumor cytotoxic T-cells in cervical lymphnodes of patie
/ 1986 / Clinical effects and toxicityof interleukin-2 in patients with cancer : 2764 ~ 72
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