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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 866 - 872 (7page)
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Invariant natural killer T (iNKT) cells develop in the thymusupon recognition of CD1d expressed on developingthymocytes. Although CD4 and CD8 coreceptorsare not directly involved in the interaction betweenCD1d and the T cell receptors (TCRs) of iNKT cells, aconspicuous lack of CD8+ iNKT cells in mice raised thequestion of whether CD8+ iNKT cells are excluded dueto negative selection during their thymic development,or if there is no lineage commitment for the developmentof murine CD8+ iNKT cells. To address this question,we analyzed iNKT cell-specific TCR Vα14+ transgenicmice, where the Vα14 transgene forces the generationof iNKT cells. This allows detailed study of theiNKT cell repertoire. We were able to identify CD8+ iNKTcells which respond to the NKT cell-specific glycolipidligand α-galactosylceramide. Unlike conventionaliNKT cells, CD8+ iNKT cells produce predominantlyIFN-γ but not IL-4 upon antigen stimulation. We alsoconfirmed the presence of CD8+ iNKT cells in wild typemice. Our results suggest that CD8+ NKT cells do existin mice, although their population size is quite small.
Their Th1-skewed phenotype might explain why thepopulation size of this subtype needs to be controlledtightly.
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참고문헌 (22)
참고문헌 신청
Ashton-Rickardt PG / 1994 / Evidence for a differential avidity model of T cell selection in the thymus / Cell 76 : 651 ~ 663
Baldwin TA / 2005 / The timing of TCR alpha expression critically influences T cell development and selection / J Exp Med 202 : 111 ~ 121
Bendelac A / 1994 / A subset of CD4+ thymocytes selected by MHC class I molecules / Science 263 : 1774 ~ 1778
Bendelac A / 1996 / Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells / J Exp Med 184 : 1285 ~ 1293
Bendelac A / 1997 / Mouse CD1-specific NK1 T cells: development, specificity, and function / Annu Rev Immunol 15 : 535 ~ 562
Baldwin TA / 2005 / The timing of TCR alpha expression critically influences T cell development and selection / J Exp Med 202 : 111 ~ 121
Bendelac A / 1994 / A subset of CD4+ thymocytes selected by MHC class I molecules / Science 263 : 1774 ~ 1778
Bendelac A / 1996 / Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells / J Exp Med 184 : 1285 ~ 1293
Bendelac A / 1997 / Mouse CD1-specific NK1 T cells: development, specificity, and function / Annu Rev Immunol 15 : 535 ~ 562
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