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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제16권 제12호
- 발행연도
- 2006.1
- 수록면
- 1,919 - 1,927 (9page)
이용수
초록· 키워드
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Tumor cells genetically engineered to secretecytokines are effective in tumor therapy, but various unexpectedside effects are observed, which may result from the bulktumor vaccines expressing various membrane-bound forms ofIL-2 (mbIL-2) on MethA fibrosarcoma cells to focus antitumorimmune responses to CTL. Chimeric forms of IL-2 with wholeCD4, deletion forms of CD4, and TNF were expressed on thetumor cell surface, respectively. Tumor clones expressingmbIL-2 or secretory form of IL-2 were able to support the celgrowth of CTLL-2, an IL-2-dependent T cel line, and theproliferation of spleen cels from 2C TCR transgenic micethat are responsive to the p2Ca/Ld MHC class I complex.of tumor cells, and the mice that once rejected the live IL-2/TNF tumor clone acquired systemic immunity against wild-type MethA cells. The IL-2/TNF clone was inferior to otherclones in tumor formation, and superior in the stimulation ofthe CD8+ T cell population in vitro. These results suggestthat the IL-2/TNF clone is the best tumor vaccine, and maystimulate CD8+ T cells by direct priming. Expression of IL-2/TNF on tumor cells may serve as an effective gene therapyrecombinant cytokine therapy and the conventional cytokinegene therapy using the secretory form of IL-2.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Assenmacher, M / 1996 / Specific expression of surface interferon-gamma on interferon-gamma producing T cells from mouse and man / Eur. J. Immunol. 26 : 263 ~ 267
Atkins, M. B / 1999 / High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993 / J. Clin. Onc
Bai, X. F / 2001 / Local costimulation reinvigorates tumor-specific cytolytic T lymphocytes for experimental therapy in mice with large tumor burdens / J. Immunol. 167 : 3936
Baskar, S / 1993 / Tumor cells expressing major histocompatibility complex class II and B7 activation molecules stimulate potent tumor-specific immunity / J. Immunother. 14 :
Blankenstein, T / 1991 / Cytokines and cancer: Experimental systems / Curr. Opin. Immunol. 3 : 694 ~ 698
Atkins, M. B / 1999 / High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993 / J. Clin. Onc
Bai, X. F / 2001 / Local costimulation reinvigorates tumor-specific cytolytic T lymphocytes for experimental therapy in mice with large tumor burdens / J. Immunol. 167 : 3936
Baskar, S / 1993 / Tumor cells expressing major histocompatibility complex class II and B7 activation molecules stimulate potent tumor-specific immunity / J. Immunother. 14 :
Blankenstein, T / 1991 / Cytokines and cancer: Experimental systems / Curr. Opin. Immunol. 3 : 694 ~ 698
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