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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 179 - 185 (7page)
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15-deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a natural ligand that activates the peroxisome proliferators- activated receptor (PPAR) γ, a member of nuclear receptor family im plicated in regulation of lipid metabolism and adipocyte differentiation. Recent studies have shown that 15d-PGJ2 is the potent anti-inflammatory agent functioning via PPARγ-dependent and -independent mechanisms. Most postulated mechanisms for anti-inflammatory action of PPARγ agonists are involved in inhibiting NF-κB signaling pathway. We examined the possibility that IL-6 signaling via the Jak-Stat pathway is modulated by 15d- PGJ2 in lymphocytes and also examined whether the inhibition of IL-6 signaling is dependent of PPARγ. 15d-PGJ2 blocked IL-6 induced Stat1 and Stat3 activation in primary human lymphocytes, Jurkat cells and immortalized rheumatoid arthritis B cells. Inhibition of IL-6 signaling was induced rapidly within 15 min after treatment of 15d-PGJ2. Other PPARγ-agonists, such as troglitazone and ciglitazone, did not inhibit IL-6 signaling, indicating that 15d- PGJ2 affect the IL-6-induced Jak-Stat signaling pathway via PPARγ-independent mechanism. Although cycloheximide reversed 15d-PGJ2-m ediated inhibition of Stat3 activation, actinomycin D had no effect on 15d-PGJ2-m ediated inhibition of IL-6 signaling, indicating that inhibition of IL-6 signaling occur independent of de novo gene expression. These results show that 15d- PGJ2 specifically inhibit Jak-Stat signaling pathway in lymphocytes, and suggest that 15d- PGJ2 may regulate inflammatory reactions through the modulation of d ifferen t signaling pathway other than NF-κB in lymphocytes.
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참고문헌 (29)
참고문헌 신청
/ / B cell stimulating factor 2/interleukin 6is a costimulant for human thymocytes and T lymphocytes : 1253 ~ 8
/ / Interleukin 2-dependent and interleukin2-independent pathways of regulation of thymocyte functionby interleukin 6 : 8643 ~ 7
/ 1986 / Complementary DNA for a novel human interleukin that induces B lymphocytes to produceimmunoglobulin : 73 ~ 2 6
/ 1997 / A family of cytokine-inducible inhibitors ofsignalling : 917 ~ 21
/ 1997 / Gp130 and the inte
/ / Interleukin 2-dependent and interleukin2-independent pathways of regulation of thymocyte functionby interleukin 6 : 8643 ~ 7
/ 1986 / Complementary DNA for a novel human interleukin that induces B lymphocytes to produceimmunoglobulin : 73 ~ 2 6
/ 1997 / A family of cytokine-inducible inhibitors ofsignalling : 917 ~ 21
/ 1997 / Gp130 and the inte
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Upregulation of Lipopolysaccharide-Induced Interleukin-10 by ProstaglandinA1 in Mouse Peritoneal Macrophages
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Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells
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STAT6 Gene Polymorphisms in Allergic Rhinitis
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Synthesis of Thienopyrimidine Derivatives as Inhibitors of STAT3 Activation Induced by IL-6
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Peroxisome proliferator-activated receptor gamma as a theragnostic target for mesenchymal-type glioblastoma patients
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Modulation of the caveolin-3 localization to caveolae and STAT3 to mitochondria by catecholamine-induced cardiac hypertrophy in H9c2 cardiomyoblasts
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