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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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We determined the effects of dietary manipulations on messenger RNA of peroxisome proliferators activated receptor isoforms (i.e., PPAR α, (β/δ, r) in red vastus lateralis muscle of rats. Total 16 male Sprague-Dawley rats were used, and animals were divided into one of two dietary conditions: either chow diet group (CHOW; n = 8) in which animals were fed with standard rodent chow (61.8% carbohydrate, 15.7% fat, 22.5% protein) or high fat diet group (FAT n = 8) in which animals were fed 24.3% carbohydrate, 52.8% fat, 22.9% protein. At the end of the 8 weeks of experimental period, red vastus lateralis muscle was dissected out from all animals, and PPAR α, β/δ, r mRNA expression was determined. There was no significant difference in body mass (BM) between CHOW and FAT. As expected, blood glucose and free fatty acid (FFA) concentration was higher in FAT than CHOW (p＜0.05), and lactate concentration was significantly lower in FAT compared to CHOW (p＜0.05). Insulin concentration tended to higher in FAT than CHOW (67.2 ± 21.9 vs. 27.0 ± 5.2 p㏖/L), but it did not reach to the statistical significance. Gene expression of PPAR a was not significantly different between CHOW and FAT. It was not also significantly different in PPAR β/δ. Interestingly, expression of mRNA in PPAR r however, was markedly depressed in FAT compared to CHOW (approximately 3 fold higher in CHOW; p＜0.05). Results obtained from present study implies that PPAR r (as compensatory function of PPAR α is expressed) possibly exerts another major tuning roles in fatty acid transport, utilization, as well as biosynthesis in skeletal muscle cells. The situations and conditions that can be postulated for this implication need to be further examined. (Korean J Nutr 2007; 40(3): 221~228)
목차
ABSTRACT
서론
연구방법
결과
고찰
결론
Literature cited
참고문헌 (35)
참고문헌 신청
Issemann I , nature1990;347 , Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators : 625 ~ 650
Gilde AJ , 2003 , Peroxisome proliferators activated receptors(PPARS):regulators of gene expression in heart and skeletal muscle 178 : 425 ~ 434
McAinch AJ , 2003 , regulation of fat oxidative gene expression in different skeletal muscle fiber types 11 : 1471 ~ 1479
Van Der Lee KA , 2000 , Effect of fatty acids on uncoupling protein 2 expression in the rat heart 14 (3) : 495 ~ 502
Wu P , 2001 , Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is medicated by peroxisome proliferators-activated receptor alpha 287 (2) : 391 ~ 396
Gilde AJ , 2003 , Peroxisome proliferators activated receptors(PPARS):regulators of gene expression in heart and skeletal muscle 178 : 425 ~ 434
McAinch AJ , 2003 , regulation of fat oxidative gene expression in different skeletal muscle fiber types 11 : 1471 ~ 1479
Van Der Lee KA , 2000 , Effect of fatty acids on uncoupling protein 2 expression in the rat heart 14 (3) : 495 ~ 502
Wu P , 2001 , Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is medicated by peroxisome proliferators-activated receptor alpha 287 (2) : 391 ~ 396
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UCI(KEPA) : I410-ECN-0101-2012-594-004190707