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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 350 - 357 (8page)
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초록· 키워드
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STATs (signal transducers and activators of transcription)
are proteins with dual functions: signal
transducers in the cytoplasm and transcriptional
activators in the nucleus. STAT proteins act as
transcription factors activated by phosphorylation
on its tyrosine residues upon stimulation by various
cytokines. The phosphorylated STAT molecules
then form homo- or heterodimers through
SH2-mediated interaction and translocate into the
nucleus to activate the transcription of various
target genes. STAT5 recognizes the interferon-γ
activated site TTCNNNGAA (GAS sequence) in the
promoter region of the β-casein gene. Except for
prolactin-dependent β-casein production in mammary
gland cells, the biological consequences of
STAT5a activation in various systems are not
clear. Here we showed that STAT5a was phosphorylated
10 min after desferrioxamine (DFO)
treatment, and reached a maximum induction at 4
h in mammary epithelial cells (HC11) and transfected
COS-7 cells. Under hypoxic conditions (2%
O2), a maximal phosphorylation of STAT5a was
observed within 6 h. EMSA (electrophoretic mobility
shift assay) showed that DFO or hypoxia enhanced
the binding activities of STAT5a DNA to
β-casein gene promoter in mammary epithelial
cells (HC11) and transfected COS-7 cells. These
results showed that DFO or hypoxia induces tyrosine
phosphorylation of STAT5a and also increases
the binding activity of STAT5a DNA in
mammary epithelial cells. Our data suggest that
the STAT5 may act as a mediator in hypoxiamediated
gene expression.
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