지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 226 - 235 (10page)
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We investigated the effect of phenylephrine (PE)- and
isoproterenol (ISO)-induced cardiac hypertrophy on
subcellular localization and expression of caveolin-3
and STAT3 in H9c2 cardiomyoblast cells. Caveolin-3
localization to plasma membrane was attenuated and
localization of caveolin-3 to caveolae in the plasma
membrane was 24.3% reduced by the catecholamineinduced
hypertrophy. STAT3 and phospho-STAT3
were up-regulated but verapamil and cyclosporin A
synergistically decreased the STAT3 and phospho-
STAT3 levels in PE- and ISO-induced hypertrophic
cells. Both expression and activation of STAT3 were increased
in the nucleus by the hypertrophy. Immunofluorescence
analysis revealed that the catecholamineinduced
hypertrophy promoted nuclear localization of
pY705-STAT3. Of interest, phosphorylation of pS727-
STAT3 in mitochondria was significantly reduced by
catecholamine-induced hypertrophy. In addition, mitochondrial
complexes II and III were greatly downregulated
in the hypertrophic cells. Our data suggest
that the alterations in nuclear and mitochondrial activation
of STAT3 and caveolae localization of caveolin-3
are related to the development of the catecholamine-
induced cardiac hypertrophy.
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참고문헌 (22)
참고문헌 신청
Alvarez BV / 2007 / Light PE, Xia Y, Karmazyn M, Casey JR. Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy / J Physiol 579 : 127 ~ 145
Anderson RG / 1998 / The caveolae membrane system / Annu Rev Biochem 67 : 199 ~ 225
Colombo F / 2001 / Beta-adrenergic stimulation of rat cardiac fibroblasts promotes protein synthesis via the activation of phosphatidylinositol 3-kinase / J Mol Cell Cardiol
Couet J / 1997 / Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities / J B
Dorn GW / 2005 / Protein kinase cascades in the regulation of cardiac hypertrophy / J Clin Invest 115 : 527 ~ 537
Anderson RG / 1998 / The caveolae membrane system / Annu Rev Biochem 67 : 199 ~ 225
Colombo F / 2001 / Beta-adrenergic stimulation of rat cardiac fibroblasts promotes protein synthesis via the activation of phosphatidylinositol 3-kinase / J Mol Cell Cardiol
Couet J / 1997 / Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities / J B
Dorn GW / 2005 / Protein kinase cascades in the regulation of cardiac hypertrophy / J Clin Invest 115 : 527 ~ 537
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