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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 588 - 600 (13page)
이용수
초록· 키워드
오류제보하기
Prostaglandin E2 (PGE2), a major product of cyclooxygenase, has been angiogenesis, vascular function, and inflammatory processes, but the underlying mechanism is not clearly elucidated. We here investigated the molecular mechanism by which PGE2 regulates angiogenesis. Treatment of human umbilical vein endothelial cells (HUVEC) with PGE2 increased angiogenesis. PGE2 increased phosphorylation of Akt and endothelial nitric oxide synthase (eNOS), eNOS activity, and nitric oxide (NO) production by the activation of cAMP-dependent protein kinase (PKA) and phosphatidylinositol 3-kinase (PI3K). Dibutyryl cAMP (DB-cAMP) mimicked the role of PGE2 in angiogenesis and the signaling pathway, suggesting that cAMP is a down-stream mediator of PGE2 2 increased endothelial cell sprouting from normal murine aortic segments, but not from eNOS-deficient ones, on Matrigel. The angiogenic effects of PGE2 were inhibited by the inhibitors of PKA, PI3K, eNOS, and soluble guanylate cyclase, but not by phospholipase C inhibitor. These results clearly show that PGE2 increased angiogenesis by activating the NO/cGMP signaling pathway through PKA/PI3K/Akt-depen-dent increase in eNOS activity.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
/ / Arias IM. Mechanism bywhich cAMP activates PI3-kinase and increases bile acidsecretion in WIF-B9 cells. Am J Physiol Cell Physiol2002
/ / Baylink DJ. Evaluationof signal transduction mechanisms for the mitogeniceffects of prostaglandin E2 in normal human bone cells invitro. J Bone Miner Res 1996 : 1413 ~ 8
/ / BenEzra D. Neovasculogenic ability of prostaglandins : 455 ~ 61
/ / Billiar TR.
/ / Billiar TR. Impaired woundhealing and angiogenesis in eNOS-deficient mice. Am JPhysiol 1999 277
/ / Baylink DJ. Evaluationof signal transduction mechanisms for the mitogeniceffects of prostaglandin E2 in normal human bone cells invitro. J Bone Miner Res 1996 : 1413 ~ 8
/ / BenEzra D. Neovasculogenic ability of prostaglandins : 455 ~ 61
/ / Billiar TR.
/ / Billiar TR. Impaired woundhealing and angiogenesis in eNOS-deficient mice. Am JPhysiol 1999 277
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