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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 768 - 776 (9page)
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초록· 키워드
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Deregulation of endothelial nitric oxide synthase (eNOS)plays an important role in the development of multiple cardiovascular diseases. Our recent study demonstrated that genistein supplementation attenuates pulmonary arterial hypertension in broilers by restoration of endothelial function. In this study, we investigated the molecular mechanism by using broiler pulmonary arterial endothelial cells (PAECs). Our results showed that genistein stimulated a rapid phosphorylation of eNOS at Ser1179 which was associated with activation of eNOS/NO axis. Further study indicated that the activation of eNOS was not mediated through estrogen receptors or tyrosine kinase inhibition, but via a phosphatidylinositol 3-kinase (PI3K)/Akt-dependent signaling pathway, as the eNOS activity and related NO release were largely abolished by pharmacological inhibitors of PI3K or Akt. Thus, our findings revealed a critical function of Akt in mediating genistein-stimulated eNOS activity in PAECs, partially accounting for the beneficial effects of genistein on the development of cardiovascular diseases observed in animal models.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Barrett-Connor E / 1991 / Estrogen and coronary heart disease in women / JAMA 265 : 1861 ~ 1867
Bernier SG / 2000 / Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase / J Biol Chem 275 : 30707 ~ 3
Boo YC / 2002 / Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A / J Biol Chem
Cassidy A / 1999 / Phyto-oestrogens:a potential role in the prevention of CHD? / Proc Nutr Soc : 193 ~ 199
Catania MA / 2002 / Oral administration of a soy extract improves endothelial dysfunction in ovariectomized rats / Planta Med 68 : 1142 ~ 1144
Bernier SG / 2000 / Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase / J Biol Chem 275 : 30707 ~ 3
Boo YC / 2002 / Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A / J Biol Chem
Cassidy A / 1999 / Phyto-oestrogens:a potential role in the prevention of CHD? / Proc Nutr Soc : 193 ~ 199
Catania MA / 2002 / Oral administration of a soy extract improves endothelial dysfunction in ovariectomized rats / Planta Med 68 : 1142 ~ 1144
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Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells
Experimental and Molecular Medicine
2005 .01
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Comparative effect of genistein and daidzein on the expression of MCP-1, eNOS, and cell adhesion molecules in TNF-α-stimulated HUVECs
Nutrition Research and Practice
2011 .10
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Comparative effect of genistein and daidzein on the expression of MCP-1, eNOS, and cell adhesion molecules in TNF-α-stimulated HUVECs
Nutrition Research and Practice
2011 .10
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한국인의 eNOS 유전자 SNP 분석
생명과학회지
2014 .02
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Extract of Rubus coreanus Fruits Increases Expression and Activity of Endothelial Nitric Oxide Synthase in the Human Umbilical Vein Endothelial Cells
생명과학회지
2011 .01
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Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase
Experimental and Molecular Medicine
2012 .01
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Carbon monoxide prevents TNF-α-induced eNOS downregulation by inhibiting NF-κB-responsive miR-155-5p biogenesis
Experimental and Molecular Medicine
2017 .01
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인체 방광암 및 백혈병세포에서 genistein에 의한 세포주기 G2/M arrest 유발에 관한 연구
생명과학회지
2006 .07
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Effect of Overexpressed Ref-1 on AKT Phosphorylation for NO Production in Mouse Aortic Endothelial Cell Line
생명과학회지
2008 .12
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Genistein의 암세포 성장 억제 기전 ( Genistein Induces G2 / M Arrest of the Cell Cycle in Human Cancer Cells )
한국생명과학회 학술발표회
2001 .01
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인체 암세포에서 genistein에 의한 cyclooxygenase-2 및 telomerase의 활성 저하
생명과학회지
2008 .06
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이소플라본 genistein이 전지방세포 성장 및 지방세포형성과정에 미치는 영향
생명과학회지
2012 .01
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The fruit of Acanthopanax senticosus Harms improves arterial stiffness and blood pressure: a randomized, placebo-controlled trial
Nutrition Research and Practice
2020 .08
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The fruit of Acanthopanax senticosus Harms improves arterial stiffness and blood pressure: a randomized, placebo-controlled trial
Nutrition Research and Practice
2020 .08
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Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice
Experimental and Molecular Medicine
2012 .01
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Shear stress stimulates phosphorylation of protein kinase A substrate proteins including endothelial nitric oxide synthase in endothelial cells
Experimental and Molecular Medicine
2006 .01
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Genistein Suppresses TPA-Induced Matrix Metalloproteinases Activity and Cell Invasion in Human Breast Adenocarcinoma Cells
생명과학회지
2012 .07
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UVB, Lithospermum erythrorhizon, Transepidermal water loss, Melanin value, Erythema index, TEM
한국현미경학회지
2008 .01
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난소절제와 Genistein 투여가 간 미토콘드리아 기능에 미치는 영향
한국영양학회지
2004 .11
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Sensitization of the Apoptotic Effect of -Irradiation in Genistein-pretreatedCaSki Cervical Cancer Cells
Journal of Microbiology and Biotechnology
2008 .01
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