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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제2호
- 발행연도
- 2008.1
- 수록면
- 392 - 395 (4page)
이용수
초록· 키워드
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In an attempt to delineate the direct effect of arseniteinduced endothelial dysfunction on nitric oxide (NO) production, confluent bovine aortic endothelial cells (BAEC) were incubated with arsenite, and endothelial NO synthase expression and NO production were measured. Exposure of arsenite decreased NO production for up to 24 h. This decrease was accompanied by decreases in cAMP, protein kinase A (PKA) activity, and furthermore, significant reduction of pCREB. In conclusion, this study is the first to demonstrate that exposure of arsenite decreases NO production by a reduction of pCREB and PKA activity that may be mediated by cAMP, leading to endothelial dysfunction.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Barua, R. S. / 2003 / Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase /
CHANG, JIN-SOO / 2007 / Isolation and ars Detoxification of Arsenite-Oxidizing Bacteria from Abandoned Arsenic-Contaminated Mines / Journal of Microbiology and Biotechnology
CHO, HYUN-JEONG / 2007 / Inhibitory Effects of Cordycepin (3'-Deoxyadenosine), a Component ofCordyceps militaris, on Human Platelet Aggregation Induced by Thapsigargin / Jour
Cho, D.-H. / 2004 / Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone. J. Biol / Chem 279 :
Harrison, D. G. / 1997 / Cellular and molecular mechanisms of endothelial cell dysfunction. J. Clin / Invest 100 : 2153 ~ 2157
CHANG, JIN-SOO / 2007 / Isolation and ars Detoxification of Arsenite-Oxidizing Bacteria from Abandoned Arsenic-Contaminated Mines / Journal of Microbiology and Biotechnology
CHO, HYUN-JEONG / 2007 / Inhibitory Effects of Cordycepin (3'-Deoxyadenosine), a Component ofCordyceps militaris, on Human Platelet Aggregation Induced by Thapsigargin / Jour
Cho, D.-H. / 2004 / Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone. J. Biol / Chem 279 :
Harrison, D. G. / 1997 / Cellular and molecular mechanisms of endothelial cell dysfunction. J. Clin / Invest 100 : 2153 ~ 2157
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