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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
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- 1 - 10 (10page)
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Pancreatic islet transplantation can corect the abnor-immunosuppressants greatly reduce the acute re-jection rate in transplant patients, the long-term side efects can be debilitating. Therefore, researchers are seeking to develop new immunosuppressive regi-mens that induce maximal levels of imunosuppres-sion with minor side effects. Rosmarinic acid (Ros A) is a secondary metabolite of certain herbs and has mul-tiple biological activities, including anti-inflamatory effects. Here, we have investigated whether treatment monoclonal antibody (MR1) improves islet allograft survival in a murine model. After transplantation, the mice were treated with either Ros A, MR1, or both (the "double" treatment). Alograft survival was prolonged in the double-treated animals compared to animals that received only Ros A or MR1. As is the case with the single-treated animals at 15 days after transplantation, the double-treated recipients did not display a sig-nificant decrease in the expression of cytokines or the ls. Infiltrating CD3+ T cells were reduced in the MR1- or double therapy relative to control or RosA group. However, at the same time point, double-treated graft showed fewer apoptotic cells and increased expression of insulin and gluca-gons, compared to the single-treatment groups. Fur-thermore, long-term (＞ 150 days) alografts that were received with double therapy exhibited larger islet clusters and contained more insulin- and gluca-conclusion, treatment with both Ros A and MR1 has a synergistic efect in murine islet allotransplantation.
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참고문헌 (24)
참고문헌 신청
Eng CP / 1991 / Inhibition of skin graft rejection in mice by rapamycin: a novel immunosuppressive macrolide / Transplant Proc 23 : 868 ~ 9
Gotoh M / 1985 / An improved method for isolation of mouse pancreatic islets / Transplantation 40 : 437 ~ 8
Hojo M / 1999 / Cyclosporine induces cancer progression by a cell-autonomous mechanism / Nature 397 : 530 ~ 4
Hur YG / 2004 / Rosmarinic acid induces p56lckdependent apoptosis in jurkat and peripheral t cells via mitochondrial pathway independent from fas/fas ligand interaction / J I
Hur YG / 2007 / Rosmarinic acid induces apoptosis of activated t cells from rheumatoid arthritis patients via mitochondrial pathway / J Clin Immunol 27 : 36 ~ 45
Gotoh M / 1985 / An improved method for isolation of mouse pancreatic islets / Transplantation 40 : 437 ~ 8
Hojo M / 1999 / Cyclosporine induces cancer progression by a cell-autonomous mechanism / Nature 397 : 530 ~ 4
Hur YG / 2004 / Rosmarinic acid induces p56lckdependent apoptosis in jurkat and peripheral t cells via mitochondrial pathway independent from fas/fas ligand interaction / J I
Hur YG / 2007 / Rosmarinic acid induces apoptosis of activated t cells from rheumatoid arthritis patients via mitochondrial pathway / J Clin Immunol 27 : 36 ~ 45
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