지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 304 - 312 (9page)
이용수
초록· 키워드
오류제보하기
Regulatory T cells (Treg), known as immune-suppressors, may help modulate the immune response. In this study, we investigated the effect of Treg-derived TGF-1 on pancreatic islet cell function in vitro and in vivo. One hundred eighty IEQ (islet equivalents) of pancreatic islets, the marginal amount to regulate blood glucose level after syngeneic islet transplantation in mouse type 1 diabetes (T1D) model, were co-cultured with 4×106 Treg cells for 48 hours. The changes in TGF-1, interleukin-6 (IL-6), and insulin secretion levels were measured and analyzed among the Treg-only group, the islet-only group, and the Treg/islet co-cultured group. In the Treg/islet co-cultured group, IL-6 and insulin secretion levels were increased (P＜ 0.0005, P＜ 0.005) and islet viability was improved (P＜0.005) compared with the islet-only group. Furthermore, after transplantation, the co-cultured islets regulated blood glucose levels efficiently in the T1D mouse model. These data suggest that Treg could improve islet functions and viability via the TGF-1 secretion pathway (P＜0.05∼0.005), thus the use of Treg in islet transplantation should be explored further.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Phase Shift in Vertical Distribution of Macroalgal Assemblages on Udo Islet, Jeju, Korea, After a Decade of Revisiting
극지연구소 초록집
2024 .07
-
Fragmentation Analysis of rIAPP Monomer, Dimer, and [MrIAPP + MhIAPP]5+ Using Collision-Induced Dissociation with Electrospray Ionization Mass Spectrometry
Mass Spectrometry Letters
2021 .12
-
Agonist (P1) Antibody Converts Stem Cells into Migrating Beta-Like Cells in Pancreatic Islets
Journal of Microbiology and Biotechnology
2022 .12
-
Petrological feature of spinel peridotite from Kurose Islet, Southwestern Japan
대한지질학회 학술대회
2015 .10
-
Post-Translational Modifications in Transcription Factors that Determine T Helper Cell Differentiation
Molecules and Cells
2021 .01
-
Investigation of Monomer and Oligomer Complexes of the Amyloidogenic Human Islet Amyloid Polypeptide 1-19 and Non-amyloidogenic Rat Islet Amyloid Polypeptide 1-19 by Electrospray Ionization-tandem Mass Spectrometry
Mass Spectrometry Letters
2024 .12
-
Implications of Calcineurin/NFAT Inhibitors" Regulation of Dendritic Cells and Innate Immune Cells in Islet Xenotransplantation
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .03
-
pep27 Mutant Immunization Inhibits Caspase-14 Expression to Alleviate Inflammatory Bowel Disease via Treg Upregulation
한국미생물학회 학술대회논문집
2022 .10
-
Tumour-Derived Reg3A Educates Dendritic Cells to Promote Pancreatic Cancer Progression
Molecules and Cells
2021 .09
-
Role of Th17 and Treg during the Chronic Infection of Hepatitis C Virus
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .12
-
부산 인근 오륙도 주변에 출현하는 만각류 유생의월별 출현 양상 변화
환경생물
2015 .01
-
GAS5 regulates viability and apoptosis in TGF-β1-stimulated bronchial epithelial cells by regulating miR-217/HDAC4 axis
Genes & Genomics
2021 .08
-
ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets
Molecules and Cells
2024 .01
-
Anti-diabetic effects of blue honeyberry on high-fed-diet-induced type II diabetic mouse
Nutrition Research and Practice
2019 .10
-
Anti-diabetic effect of purple corn extract on C57BL/KsJ db/db mice
Nutrition Research and Practice
2015 .02
-
Anti-diabetic effect of purple corn extract on C57BL/KsJ db/db mice
Nutrition Research and Practice
2015 .02
-
Differential Effects of Transforming Growth Factor-β on NKG2D Ligands Expression and NK Cell-mediated Immune Responses in Primary and Metastatic Colon Cancer
생명과학회지
2023 .02
-
A Review on Multidecadal Coastal Changes at Funafuti, Tuvalu from 1897 to 2015
대한원격탐사학회지
2023 .02
-
Blockade of Retinol Metabolism Protects T Cell-Induced Hepatitis by Increasing Migration of Regulatory T Cells
Molecules and Cells
2015 .11
-
D-Xylose as a sugar complement regulates blood glucose levels by suppressing phosphoenolpyruvate carboxylase (PEPCK) in streptozotocin-nicotinamide-induced diabetic rats and by enhancing glucose uptake in vitro
Nutrition Research and Practice
2016 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0