지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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- 자료유형
- 학술저널
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- 2013.1
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Cytokines activate several inflammatory signals that mediate b-cell destruction. We recently determined that SPA0355 is a strong anti-inflammatory compound, thus reporting its efficacy in protecting b cells from various insults. The effects of SPA0355 on b-cell survival were studied in RINm5F cells and primary islets. The protective effects of this compound on the development of type 1 diabetes were evaluated in non-obese diabetic (NOD) mice. SPA0355 completely prevented cytokineinduced nitric oxide synthase (iNOS) expression and cytotoxicity in RINm5F cells and isolated islets. The molecular mechanism of SPA0355 inhibition of iNOS expression involves the inhibition of nuclear factor jB and Janus kinase signal transducer and activator of transcription pathways. The protective effects of SPA0355 against cytokine toxicity were further demonstrated by normal insulin secretion and absence of apoptosis of cytokine-treated islets. In experiments with NOD mice, the occurrence of diabetes was efficiently reduced when the mice were treated with SPA0355. Therefore, SPA0355 might be a valuable treatment option that delays the destruction of pancreatic b cells in type 1 diabetes.
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참고문헌 (34)
참고문헌 신청
Gonzalez-Gay MA / 2009 / Short-term effect of anti- TNF-a therapy on nitric oxide production in patients with severe rheumatoid arthritis / Clin Exp Rheumatol 27:452~458
Prado CM / 2006 / Effects of nitric oxide synthases in chronic allergic airway inflammation and remodeling / Am J Respir Cell Mol Biol 35:457~465
Connelly L / 2005 / Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo / J Biol Chem 280:10040~10046
Beck PL / 2007 / Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation / Gastroenterology 132:1778~1790
Cnop M / 2005 / Mechanisms of pancreatic b-cell death in type 1 and type 2 diabetes: many differences, few similarities / Diabetes 54:S97~S107
Prado CM / 2006 / Effects of nitric oxide synthases in chronic allergic airway inflammation and remodeling / Am J Respir Cell Mol Biol 35:457~465
Connelly L / 2005 / Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo / J Biol Chem 280:10040~10046
Beck PL / 2007 / Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation / Gastroenterology 132:1778~1790
Cnop M / 2005 / Mechanisms of pancreatic b-cell death in type 1 and type 2 diabetes: many differences, few similarities / Diabetes 54:S97~S107
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