지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 260 - 267 (8page)
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초록· 키워드
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Type 1 diabetes mellitus is caused by the autoimmune destruction of β cells within the islets. In recent years,innate immunity has been proposed to play a key role in this process. High-mobility group box 1 (HMGB1), an inflammatory trigger in a number of autoimmune diseases,activates proinflammatory responses following its release from necrotic cells. Our aim was to determine the significance of HMGB1 in the natural history of diabetes in non-obese diabetic (NOD) mice. We observed that the rate of HMGB1 expression in the cytoplasm of islets was much greater in diabetic mice compared with non-diabetic mice. The majority of cells positively stained for toll-like receptor 4 (TLR4) were βcells; few α cells were stained for TLR4. Thus, we examined the effects of anti-TLR4 antibodies on HMGB1 cell surface binding, which confirmed that HMGB1 interacts with TLR4 in isolated islets. Expression changes in HMGB1 and TLR4 were detected throughout the course of diabetes. Our findings indicate that TLR4 is the main receptor on β cells and that HMGB1 may signal via TLR4 to selectively damage β cells rather than αcells during the development of type 1 diabetes mellitus.
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참고문헌 (25)
참고문헌 신청
Abdulahad DA / 2010 / HMGB1 in systemic lupus Erythematosus: Its role in cutaneous lesions development / Autoimmun Rev 9 : 661 ~ 665
Anderson MS / 2005 / The NOD mouse: A model of immune dysregulation / Annu Rev Immunol 23 : 447 ~ 485
Devaraj S / 2011 / Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes / Cytokines 55 : 441 ~ 445
Gdynia G / 2010 / Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria / Cancer Res 70 : 8558 ~ 8568
Giarratana N / 2004 / A vitamin D analog down-regulates proinflammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes developmen
Anderson MS / 2005 / The NOD mouse: A model of immune dysregulation / Annu Rev Immunol 23 : 447 ~ 485
Devaraj S / 2011 / Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes / Cytokines 55 : 441 ~ 445
Gdynia G / 2010 / Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria / Cancer Res 70 : 8558 ~ 8568
Giarratana N / 2004 / A vitamin D analog down-regulates proinflammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes developmen
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