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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 606 - 615 (10page)
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Abstract Our previous study has demonstrated that there is a significant delay of Balb/c cardiac allograft rejection in the C57BL/6 4-1BB-deficient knockout recipient. In this study, we examined the effect of combined blockade of the 4-1BB and CD28 costimulatory pathways on cardiac allograft rejection in the C57BL/6 → Balb/c model. A long-term cardiac allograft survival was induced in CD28/4-1BBdeficient mice (＞ 100 days survival in 3 of 4 mice), which was comparable with CD28-deficient mice (＞ 100 days survival in 2 of 5 mice; P ＜ 0.2026). There was no long-term cardiac allograft survival in either wild-type (WT) or 4-1BB-deficient mice, even though 4-1BB-deficient recipients showed a significant delay of cardiac allograft rejection than WT mice. An in vitro mixed leukocyte reaction (MLR) assay showed that 4-1BB-deficient and WT mouse T cells had a similar responsiveness to allostimulation, whereas CD28- and CD28/4-1BB-deficient mouse T cells had a defective responsiveness to allostimu - lation. Furthermore, 4-1BB-deficient mice showed a similar CTL but an elevated Ab response against alloantigens as compared to WT mice, and the alloimmune responses of 4-1BB-deficient mice were abrogated in the CD28-deficient background. Ove - rall, these results indicate that the CD28 costimu - latory pathway plays a major role in the alloimmune response and that 4-1BB signals are dependent upon CD28 signals.
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참고문헌 (27)
참고문헌 신청
/ / Molecular cloning a ligand for the inducible T cell gene 4-1BB a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur J Immunol 1993 : 2
/ / New insights into the role of 4-1BB in immune responses 23 : 378 ~ 380
/ 1995 / Nave CD28-deficient T cells can initiate but not sustain an in vitro an-tigen-specific immune response. 154
/ 1996 / The in vivo mechanisms of action of CTLA4Ig. 156 : 2294 ~ 2299
/ 1997 / Costimu-lation of CD28- T lymphocytes by 4-1BB ligand. 158 : 551 ~ 559
/ / New insights into the role of 4-1BB in immune responses 23 : 378 ~ 380
/ 1995 / Nave CD28-deficient T cells can initiate but not sustain an in vitro an-tigen-specific immune response. 154
/ 1996 / The in vivo mechanisms of action of CTLA4Ig. 156 : 2294 ~ 2299
/ 1997 / Costimu-lation of CD28- T lymphocytes by 4-1BB ligand. 158 : 551 ~ 559
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