지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 365 - 370 (6page)
이용수
초록· 키워드
오류제보하기
Mesial temporal lobe epilepsy (MTLE) is associ-ated with severe neuronal death and reactive gliosis in hipocampus. However, the molecular mechanisms underlying these pathological chan-ges remain unanswered. ERK has been reported chronically activated in reactive glia of human epil-eptic hipocampus. In the present study, we in-vestigated which of the downstream signaling mol-ecules of ERK would be involved in MTLE. Wes-tern blot analysis demonstrated that CREB and Increase in the active forms of CREB and p90RSK resulted not only from the increase in their phos-phorylation levels but also from the increase in the protein levels. Activation of CREB and p90RSK was noted in the whole subfields of hippocampus with Amon's horn sclerosis (AHS) representing a distinctive cellular distribution. However, the comon major change was present in proliferating reactive astrocytes. In contrast, their activation spite the presence of a number of astrocytes ex-pressing high levels of GFAP. Our results demon-strate that chronic activation CREB and p90RSK in the epileptic hipocampus may be closely as-sociated with the histopathological changes of AHS.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
p90RSK Activation Promotes Epithelial-Mesenchymal Transition in Cisplatin-Treated Triple-Negative Breast Cancer Cells
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2019 .12
-
The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles
Experimental and Molecular Medicine
2016 .01
-
Cloning and Characterization of p90Rsk in Frog Oocytes
한국동물학회 학술대회
2000 .01
-
Regulation of Human Period1 Promoter Is Involved with CREB Activation by MAP Kinase Pathway in Human Neuroblastoma Cell Line
한국동물학회 학술대회
2003 .01
-
Temporal Profile of CREB Expression in Mouse Testis during Postnatal Development and Spermatogenesis
한국생명과학회 심포지움
2008 .10
-
HIV-1 Nef Decreased the Transcription Activity of the CREB-2
한국동물학회 학술대회
2000 .01
-
Activation of CREB by PKA Promotes the Chondrogeneic Differentiation of Chick Limb Bud Mesenchymal Cells
Animal cells and systems
2009 .01
-
LPS-stimulated Macrophage Activation Affects Endothelial Dysfunction
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2018 .03
-
$Ca^{2+}$ Enhanced the Cell-Cell Interactions via FN and Its Receptors at the Early Condensation Period of Chondrogenic Differentiation by Activating CREB through CaM II Kinase
한국동물학회 학술대회
1995 .01
-
New Four-herb Formula Ameliorates Memory Impairments via Neuroprotective Effects on Hippocampal Cells
생명과학회지
2016 .04
-
Pathogenic effect of a cell-penetrating anti-dsDNA autoantibody through p38 signaling pathway and pro-inflammatory cytokine stimulation in mesangial cells
Animal cells and systems
2018 .01
-
PAK4 signaling in health and disease: defining the PAK4–CREB axis
Experimental and Molecular Medicine
2019 .01
-
Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells
Experimental and Molecular Medicine
2009 .01
-
Protein kinase A mediates microglial activation induced by plasminogen and gangliosides
Experimental and Molecular Medicine
2004 .01
-
Deciphering the star codings: astrocyte manipulation alters mouse behavior
Experimental and Molecular Medicine
2020 .01
-
ERK1/2 activation by the C. elegans muscarinic acetylcholine receptor GAR-3 in cultured mammalian cells involves multiple signaling pathways
Animal cells and systems
2010 .01
-
Black rice extract protected HepG2 cells from oxidative stress-induced cell death via ERK1/2 and Akt activation
Nutrition Research and Practice
2014 .04
-
Black rice extract protected HepG2 cells from oxidative stress-induced cell death via ERK1/2 and Akt activation
Nutrition Research and Practice
2014 .04
-
Downstream molecular events in the altered profiles of lysophosphatidic acid-induced cAMP in senescent human diploid fibroblasts
Experimental and Molecular Medicine
2006 .01
-
Proteomic analysis of human cerebral cortex in epileptic patients
Experimental and Molecular Medicine
2004 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0