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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 461 - 467 (7page)
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In the injured brain, microglia is known to be activated and produce proinflamatory media-tors such as interleukin-1β (IL-1β), tumor necro-sis factor-α (TNF-α) and inducible nitric oxide protein kinase A (PKA) in microglial activation by both plasminogen and gangliosides in rat primary microglia and in the BV2 imortalized murine microglial cell line. Both plasminogen and gangliosides induced IL-1β, TNF-α and iNOS mRNA expression, and that this expression was inhibited by the addition of the PKA inhibitors, KT5720 and H89. Both plasminogen and gan-gliosides activated PKA and increased the DNA binding activity of the cAMP response element- binding protein (CREB). Furthermore, KT5720 CREB and NF-κB in plasminogen-treated cells. These results sugest that PKA plays an im-portant role in plasminogen and gangliosides- induced microglial activation.
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참고문헌 (29)
참고문헌 신청
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/ / Characterization of microglialreaction after middle cerebral artery occlusion in ratbrain : 123 ~ 32
/ / Characterizationof a functional NF-kappa B site in the humaninterleukin 1 beta promoter evidence for a positive autoregulatoryloop : 6231 ~ 40
/ / Microglial mitogens are produced in the developing andinjured mammalian brain : 323 ~ 33
/ / Regulation of tumornecrosis factor alpha transcription in macrophages involvementof four kappa B-like motifs and of constitutive andinducible forms of NF-kappa B : 1498 ~
/ / Characterization of microglialreaction after middle cerebral artery occlusion in ratbrain : 123 ~ 32
/ / Characterizationof a functional NF-kappa B site in the humaninterleukin 1 beta promoter evidence for a positive autoregulatoryloop : 6231 ~ 40
/ / Microglial mitogens are produced in the developing andinjured mammalian brain : 323 ~ 33
/ / Regulation of tumornecrosis factor alpha transcription in macrophages involvementof four kappa B-like motifs and of constitutive andinducible forms of NF-kappa B : 1498 ~
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