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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 547 - 554 (8page)
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TGF-β-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved in the pathogenesis of Th1-mediated autoimmune joint inflammation and Th2-mediated allergic pulmonary inflammation. In this study, we investigated the effect of CD1d-restricted NKT cells in the Tol-APCs-mediated suppression of autoimmune disease using a murine CIA model. When CIA-induced mice were treated with Tol-APCs obtained from CD1d+/- or CD1d-/- mice, unlike CD1d+/-APCs, CD1d-/- Tol-APCs failed to suppress CIA. More specifically, CD1d-/- Tol-APCs failed to suppress the production of inflammatory cytokines and the induction of Th2 responses by antigen-specific CD4 T cells both in vitro and in vivo. Our results demonstrate that the presence of CD1d-restricted NKT cells is critical for the induction of Tol-APCs-mediated suppression of CIA.
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참고문헌 (23)
참고문헌 신청
Bendelac A / 1997 / Mouse CD1-specific NK1 T cells: development, specificity, and function / Annu Rev Immunol 15 : 535 ~ 562
Chiba A / 2004 / Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosinetruncated analog of alpha-galactosylceramide / Arthritis
Chiba A / 2005 / The involvement of V(alpha)14 natural killer T cells in the pathogenesis of arthritis in murine models / Arthritis Rheum 52 : 1941 ~ 1948
Coppieters K / 2007 / A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner / J Immuno
Courtenay JS / 1980 / Immunisation against heterologous type II collagen induces arthritis in mice / Nature 283 : 666 ~ 668
Chiba A / 2004 / Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosinetruncated analog of alpha-galactosylceramide / Arthritis
Chiba A / 2005 / The involvement of V(alpha)14 natural killer T cells in the pathogenesis of arthritis in murine models / Arthritis Rheum 52 : 1941 ~ 1948
Coppieters K / 2007 / A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner / J Immuno
Courtenay JS / 1980 / Immunisation against heterologous type II collagen induces arthritis in mice / Nature 283 : 666 ~ 668
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