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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 176 - 184 (9page)
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We investigated the co-stimulatory role of a cellsurface
protein, CD99. Co-ligation of CD99 and
suboptimal CD3 induced T-cell activation to a level
comparable to that obtained with optimal CD3 or
CD3+CD28. We also noted concomitant enhancement
of the earliest T-cell receptor (TCR) signaling
events. In addition, co-ligation of CD99 and CD3 led
to translocation of TCR complexes into the lipid raft,
without concomitant migration of CD99 to the raft,
and consequent enhancement of TCR ζ-mediated
signal 1. These data demonstrate the unique pro -
perties of CD99 co-stimulation that distinguish this
molecule from CD28 and other raft-resident costimulatory
factors.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Alegre ML / 2001 / T-cell regulation by CD28 and CTLA-4 1 : 220 ~ 228
Badour K / 2003 / The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse 18 : 141 ~
Bernard G / 1995 / The E2 molecule (CD99) specifically triggers homotypic aggregation of CD4+CD8+ thymocytes 154 : 26 ~ 32
Bernard G / 1997 / Apoptosis of immature thymocytes mediated by E2/CD99 158 : 2543 ~ 2550
Bernard G / 2000 / CD99 (E2) up-regulates alpha-4beta1-dependent T cell adhesion to inflamed vascular endothelium under flow conditions 30 : 3061 ~ 3065
Badour K / 2003 / The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse 18 : 141 ~
Bernard G / 1995 / The E2 molecule (CD99) specifically triggers homotypic aggregation of CD4+CD8+ thymocytes 154 : 26 ~ 32
Bernard G / 1997 / Apoptosis of immature thymocytes mediated by E2/CD99 158 : 2543 ~ 2550
Bernard G / 2000 / CD99 (E2) up-regulates alpha-4beta1-dependent T cell adhesion to inflamed vascular endothelium under flow conditions 30 : 3061 ~ 3065
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