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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 187 - 194 (8page)
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Collagen-induced arthritis (CIA) is mediated by self-reactive CD4+ T cells that produce inflammatory cytokines. TGF-β2-treated tolerogenic antigen-presenting cells (Tol-APCs) are known to induce tolerance in various autoimmune diseases. In this study, we investigated whether collagen-specific Tol-APCs could induce suppression of CIA. We observed that Tol-APCs could suppress the development and severity of CIA and delay the onset of CIA. Treatment of Tol-APCs reduced the number of IFN-γ- and IL-17-producing CD4+ T cells and increased IL-4- and IL-5-producing CD4+ T cells upon collagen antigen stimulation in vitro. The suppression of CIA conferred by Tol-APCs correlated with their ability to selectively induce IL-10 production. We also observed that treatment of Tol-APCs inhibited not only cellular immune responses but also humoral immune responses in the process of CIA. Our results suggest that in vitro-generated Tol-APCs have potential therapeutic value for the treatment of rheumatoid arthritis as well as other autoimmune diseases.
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참고문헌 (23)
참고문헌 신청
Akbari O / 2003 / Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity / Nat Med 9 : 582 ~ 588
Baron EJ / 1982 / Elicitation of peritoneal polymorphonuclear neutrophils from mice / J Immunol Methods 49 : 305 ~ 313
Brand DD / 2007 / Collagen-induced arthritis / Nat Protoc 2 : 1269 ~ 1275
Chiba A / 2005 / The involvement of V(alpha)14 natural killer T cells in the pathogenesis of arthritis in murine models / Arthritis Rheum 52 : 1941 ~ 1948
Courtenay JS / 1980 / Immunisation against heterologous type II collagen induces arthritis in mice / Nature 283 : 666 ~ 668
Baron EJ / 1982 / Elicitation of peritoneal polymorphonuclear neutrophils from mice / J Immunol Methods 49 : 305 ~ 313
Brand DD / 2007 / Collagen-induced arthritis / Nat Protoc 2 : 1269 ~ 1275
Chiba A / 2005 / The involvement of V(alpha)14 natural killer T cells in the pathogenesis of arthritis in murine models / Arthritis Rheum 52 : 1941 ~ 1948
Courtenay JS / 1980 / Immunisation against heterologous type II collagen induces arthritis in mice / Nature 283 : 666 ~ 668
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