지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 424 - 431 (8page)
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White fat cells secrete adipokines that induce inflammation and obesity has been reported to be characterized by high serum levels of inflammatory cytokines such as IL-6 and TNF-α. Rheumatoid arthritis (RA) is a prototype of inflammatory arthritis,but the relationship between RA and obesity is controversial. We made an obese inflammatory arthritis model: obese collagen-induced arthritis (CIA). C57BL/6 mice were fed a 60-kcal high fat diet (HFD) from the age of 4 weeks and they were immunized twice with type II collagen (CII). After immunization, the obese CIA mice showed higher arthritis index scores and histology scores and a more increased incidence of developing arthritis than did the lean CIA mice. After treatment with CII, mixed lymphocyte reaction also showed CII-specific response more intensely in the obese CIA mice than lean CIA. The anti-CII IgG and anti-CII IgG2a levels in the sera of the obese CIA mice were higher than those of the lean CIA mice. The number of Th17 cells was higher and the IL-17 mRNA expression of the splenocytes in the obese CIA mice was higher than that of the lean CIA mice. Obese CIA mice also showed high IL-17 expression on synovium in immunohistochemistry. Although obesity may not play a pathogenic role in initiating arthritis, it could play an important role in amplifying the inflammation of arthritis through the Th1/Th17 response. The obese CIA murine model will be an important tool when we investigate the effect of several therapeutic target molecules to treat RA.
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참고문헌 (23)
참고문헌 신청
Andersson N / 2010 / A variant near the interleukin-6 gene is associated with fat mass in Caucasian men / Int J Obes 34 : 1011 ~ 1019
Bokarewa M / 2005 / Resistin, an adipokine with potent proinflammatory properties / J Immunol 174 : 5789 ~ 5795
Carman WJ / 1994 / Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study / Am J Epidemiol 139 : 119 ~ 129
Croci T / 2007 / Effect of the cannabinoid CB1 receptor antagonist rimonabant on nociceptive responses and adjuvant-induced arthritis in obese and lean rats / Br J Pharmacol
Griffin TM / 2010 / Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice / Arthritis Res Ther 12 : R
Bokarewa M / 2005 / Resistin, an adipokine with potent proinflammatory properties / J Immunol 174 : 5789 ~ 5795
Carman WJ / 1994 / Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study / Am J Epidemiol 139 : 119 ~ 129
Croci T / 2007 / Effect of the cannabinoid CB1 receptor antagonist rimonabant on nociceptive responses and adjuvant-induced arthritis in obese and lean rats / Br J Pharmacol
Griffin TM / 2010 / Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice / Arthritis Res Ther 12 : R
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