지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 65 - 70 (6page)
이용수
초록· 키워드
오류제보하기
to increase vascular permeability to macromolecules.
Angiotensin II can stimulate the release of VEGF, and the protective effects of angiotensin II antagonist against diabetic glomerular injury suggest that the angiotensin II-induced VEGF is an important pathogenetic mechanism in the development of proteinuria during diabetic nephropathy although this mechanism is not fully understood.
In this study, the changes of VEGF expression was examined in the experimental diabetic nephropathy to determine whether these changes were modified by renoprotective intervention by blockers of angiotensin II receptors. The streptozotocininduced diabetic rats were treated with L-158,809, a blocker of angiotensin II receptors, for 12 weeks.
Age-matched rats with L-158,809 served as controls.
RT-PCR and immunohistochemistry were used to assess and quantify gene and protein expression of VEGF. A progressive increase in urinary protein excretion was observed in diabetic rats. Glomerular VEGF expression was significantly higher in diabetic rats than in the control groups, with a significant reduction in glomerular VEGF expression and proteinuria in L-158,809- treated diabetic rats. VEGF mRNA was also significantly higher in diabetic kidneys than in the control groups, with a significant reduction in VEGF mRNA in L-158,809-treated diabetic kidneys.
These results demonstrates that VEGF expression is significantly increased in diabetic podocytes, and angiotensin II receptor antagonist attenuated these changes in VEGF expression and prevented the development of proteinuria in vivo. Attenuation of increased VEGF expression in podocytes could contribute to the renoprotective effects of angiotensin II receptor antagonists in diabetic nephropathy.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
/ / A role for podocytes to counteract capillary wall distension (biling r) : 369 ~ 76
/ / Effect of angiotensin II on glomerularhemodynamics and ultrafiltration coefficient
/ / Estimation of glomerularvolume a comparison of four methods
/ / Validation in awake rats of a tail-cuff method formeasuring systolic pressure : 279 ~ 82
/ 1995 / Angiotensin IIincreases vascular permeability factor gene expression by humanvascular smooth muscle cells : 913 ~ 7
/ / Effect of angiotensin II on glomerularhemodynamics and ultrafiltration coefficient
/ / Estimation of glomerularvolume a comparison of four methods
/ / Validation in awake rats of a tail-cuff method formeasuring systolic pressure : 279 ~ 82
/ 1995 / Angiotensin IIincreases vascular permeability factor gene expression by humanvascular smooth muscle cells : 913 ~ 7
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
An antioxidant modulates expression of receptor activator of NF-κB in asthma
Experimental and Molecular Medicine
2006 .01
-
Angiotensin-I converting enzyme gene polymorphism in Turkish type 2 diabetic patients
Experimental and Molecular Medicine
2004 .01
-
당뇨병성 망막증에 있어서 Captopril에 의한 VEGF 발현 저하 효과
한국현미경학회지
2009 .01
-
A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity
Experimental and Molecular Medicine
2010 .01
-
홍경천 추출물이 Streptozotocin으로 유도된 당뇨쥐에 미치는 영향
동아시아식생활학회지
2005 .04
-
Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy
Experimental and Molecular Medicine
2017 .01
-
TGF-β1 induces mouse dendritic cells to express VEGF and its receptor (Flt-1) under hypoxic conditions
Experimental and Molecular Medicine
2010 .01
-
Combined blockade of HER2 and VEGF exerts greater growth inhibition of HER2-overexpressing gastric cancer xenografts than individual blockade
Experimental and Molecular Medicine
2013 .01
-
Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes
Experimental and Molecular Medicine
2011 .01
-
The discovery of placenta growth factor and its biological activity
Experimental and Molecular Medicine
2012 .01
-
Effective glycemic control achieved by transplanting non-viral cationic liposome-mediated VEGF-transfected islets in streptozotocin-induced diabetic mice
Experimental and Molecular Medicine
2005 .01
-
당뇨 유발 흰쥐에서 여주열매 첨가 시 혈당과 콜레스테롤 수준에 미치는 영향
동아시아식생활학회지
2013 .12
-
녹차가루가 당뇨 쥐의 골 대사 지표 및 골밀도에 미치는 영향
동아시아식생활학회지
2013 .12
-
녹차가루 식이가 당뇨쥐의 혈당 및 혈중 지질 농도에 미치는 영향
동아시아식생활학회지
2010 .02
-
High efficiency transduction of human VEGF165 into human skeletal myoblasts: in vitro studies
Experimental and Molecular Medicine
2003 .01
-
Heat shock protein 90 regulates IκB kinase complex and NF-κB activation in angiotensin II-induced cardiac cell hypertrophy
Experimental and Molecular Medicine
2010 .01
-
Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells
Molecules and Cells
2019 .01
-
Orphan nuclear receptor small heterodimer partner inhibits angiotensin II- stimulated PAI-1 expression in vascular smooth muscle cells
Experimental and Molecular Medicine
2010 .01
-
당뇨병 환자를 위한 고식이섬유 보충물의 개발을 위한 연구(Ⅰ) : 해조류 투여가 당뇨쥐의 장기기능과 증세호전도에 미치는 영향
한국영양학회지
1996 .04
-
TGF-β1 induces VEGF expression in human granulosa-lutein cells: a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome
Experimental and Molecular Medicine
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0