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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 429 - 439 (11page)
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Small heterodimer partner (SHP) is an atypical member of nuclear receptor superfamily that lacks a DNA-binding domain. In previous study, we showed that SHP, c-jun, p65 of NF-κB subunits, and p21WAF1 expression was increased during monocytic differentiaton with the exposure of human leukemia cells to a differentiation agent, PMA. In this study, c-Jun and p65 were shown to mediate the transcriptional activation of the SHP promoter. In addition, SHP induced the cell cycle regulatory protein levels and cooperatively increased an induction of p21WAF1 expression with p65. Furthermore, SHP protected differentiated cells from etoposide-induced cellular apoptosis through the induction and cytoplasmic sequestration of p21WAF1. Complex formation between SHP and p21WAF1 was demonstrated by means of coimmunoprecipitation.
These results suggest that SHP prolongs a cellular survival of differentiating monocytes through the transcriptional regulation of target genes of cell survival and differentiation.
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참고문헌 (23)
참고문헌 신청
Andres V / 1996 / Myogenin expression, cell cycle withdrawal, and phenotypic differentiation are temporally separable events that precede cell fusion upon myogenesis / J Cell
Angel P / 1988 / The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1 / Cell 55 : 875 ~ 885
Asada M / 1999 / Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation / Embo J 18 : 1223 ~ 1234
Baeuerle PA / 1994 / Function and activation of NF-kappa B in the immune system / Annu Rev Immunol 12 : 141 ~ 179
Borgius LJ / 2002 / Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP / J Biol Chem 277 : 49761 ~ 49766
Angel P / 1988 / The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1 / Cell 55 : 875 ~ 885
Asada M / 1999 / Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation / Embo J 18 : 1223 ~ 1234
Baeuerle PA / 1994 / Function and activation of NF-kappa B in the immune system / Annu Rev Immunol 12 : 141 ~ 179
Borgius LJ / 2002 / Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP / J Biol Chem 277 : 49761 ~ 49766
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Effects of Cholic Acid/CDCA and FGF-19 on the Protein Levels of the Endogenous Small Heterodimer Partner (SHP) in the Mouse Liver and HepG2 Cells
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Induction of Cell Cycle Arrest by Cyclic AMP in Tumor Cells through p53-independent Transcriptional Regulation of Cdk inhibitor p21WAF1/CIP1
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IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1
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The Long-term Changes of Siberian High and Winter Climate over the Northern Hemisphere
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Transcriptional repression of p21waf1 by hepatitis C virus NS3 protein in a p53-dependent pathway
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Chlorpromazine activates p21Waf1/Cip1 gene transcription via early growth response-1 (Egr-1) in C6 glioma cells
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Transcriptional repression of p21waf1 promoter by hepatitis B virus X protein via a p53-independent pathway
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항공기상서비스 선진화를 위한 WAFS 활용기술 국산화 개발
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한국인에서 획득한 Helicobacter pylori의 CagA에 존재하는 SHP-2 binding site의 분석
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Differential modulation of zinc-stimulated p21Cip/WAF1 and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells
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Trichostatin A-mediated upregulation of p21WAF1contributes toosteoclast apoptosis
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Insulin-dependent suppression of cholesterol 7α-hydroxlase is a possible link between glucose and cholesterol metabolisms
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Transcriptional activity of the human GM3 synthase (hST3Gal V) gene during the monocytic differentiation of HL-60 cells induced by PMA
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2003 .05
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INVOLVEMENT OF p21(WAF1/CIP1) IN MITOMYCI C-INDUCED G2 ARREST IN LP1-1 CELLS
한국동물학회 학술대회
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The repressive activity of hepatitis C virus core protein on the transcription of p21waf1 is regulated by protein kinase A- mediated phosphorylation
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