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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 106 - 113 (8page)
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초록· 키워드
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The migration of vascular smooth muscle cells (VSMCs) into the intima, an important step in injury-induced neointimal hyperplasia, requires the activation of nuclear factor-κB (NF-κB) and the consequent up-regulation of matrix metallopro-teinase-9 (MMP-9). This study was undertaken to test for a possible effect of α-lipoic acid (ALA), a potent inhibitor of NF-.B, on MMP-9 expression. ALA inhibited high-glucose- and TNF-α-stimulated VSMC migrations in vitro. It also inhibited high-glucose- and TNF-α-induced increases in MMP-9 expression. The activity of MMP-9-promoter constructs with mutations in the NF-κB binding site was not inhibited by ALA, indicating an involvement of the NF-κB signaling pathway in the AL A-specific inhibition of MMP-9. These data suggest the possibility that ALA may be useful for the prevention of neointimal hyper-plasia after angioplasty, by inhibiting the NF-κB/ MMP-9 pathway, especially with hyperglycemia.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Ahn JD / 2001 / Transcription factor decoy for activator protein-1 (AP-1) inhibits high glucose- and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gen
Baldwin AS Jr / 1996 / The NF-kappa B and I kappa B proteins: new discoveries and insights 14 : 649 ~ 683
Bast A / / Haenen GR. Interplay between lipoic acid andglutathione in the protection against microsomal lipidperoxidation. Biochim Biophys Acta 1988 : 558 ~ 61
Bond M / 2001 / Inhibition of transcription factor NF-kappaB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells 50 : 556 ~ 565
Bourcier T / 1997 / The nuclear factor kappa-B signaling pathway participates in dysregulation of vascular smooth muscle cells in vitro and in human atherosclerosis 272 : 158
Baldwin AS Jr / 1996 / The NF-kappa B and I kappa B proteins: new discoveries and insights 14 : 649 ~ 683
Bast A / / Haenen GR. Interplay between lipoic acid andglutathione in the protection against microsomal lipidperoxidation. Biochim Biophys Acta 1988 : 558 ~ 61
Bond M / 2001 / Inhibition of transcription factor NF-kappaB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells 50 : 556 ~ 565
Bourcier T / 1997 / The nuclear factor kappa-B signaling pathway participates in dysregulation of vascular smooth muscle cells in vitro and in human atherosclerosis 272 : 158
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