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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 97 - 105 (9page)
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초록· 키워드
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Expression of matrix metalloproteinase-9 (MMP-9) is
associated with airway remodeling and tissue injury
in asthma. However, little is known about how MMP-9
is up-regulated in airway epithelial cells. In this study,
we show that phorbol myristate acetate (PMA)
induces MMP-9 expression via a protein kinase Cα
(PKCα)-dependent signaling cascade in BEAS-2B
human lung epithelial cells. Pretreatment with either
GF109203X, a general PKC inhibitor, or Gö6976, a
PKCα/β isozyme inhibitor, inhibited PMA-induced
activation of the MMP-9 promoter, as did transient
transfection with PKCα antisense oligonuclotides.
PMA activated NF-κB by phosphorylating IκB in
these cells and this was also inhibited by GF109203X
and Gö6976, suggesting that PKCα acts as an
upstream regulator of NF-κB in PMA-induced MMP-9
induction. Our results indicate that a “PKCα-NF-
κB”-dependent cascade is involved in the signaling
leading to PMA-induced MMP-9 expression in the
lung epithelium.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Atkinson JJ / 2003 / Matrix metalloproteinase-9 in lung remodeling 28 : 12 ~ 24
Bove PF / 2007 / Nitric oxide promotes airway epithelial wound repair through enhanced activation of MMP-9 36 : 138 ~ 146
Cataldo DD / 2002 / Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperres-ponsiveness during allergen-induced airway inflammation 161 : 4
Chakraborti S / 2003 / Regulation of matrix metalloproteinases: an overview 253 : 269 ~ 285
Chou YT / 2006 / Cited2 modulates TGF-beta-mediated upregulation of MMP9 25 : 5547 ~ 5560
Bove PF / 2007 / Nitric oxide promotes airway epithelial wound repair through enhanced activation of MMP-9 36 : 138 ~ 146
Cataldo DD / 2002 / Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperres-ponsiveness during allergen-induced airway inflammation 161 : 4
Chakraborti S / 2003 / Regulation of matrix metalloproteinases: an overview 253 : 269 ~ 285
Chou YT / 2006 / Cited2 modulates TGF-beta-mediated upregulation of MMP9 25 : 5547 ~ 5560
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Interleukin - 1β stimulates matrix metalloproteinase-2 expression via a prostaglandin E2 -dependent mechanism in human chondrocytes
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갯메꽃 추출물과 유기용매 분획물의 암전이 억제 효과
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