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The chemopreventive effects of naringenin derived from citrus on tumor migration
and the possible mechanisms involved in this protection were investigated in HT-1080 tumor cells.
In this study, we found that naringenin reduced phorbol 12-myristate 13-acetate (PMA)-enhanced
matrix metalloproteinases (MMP)-9 activation in a dose-dependant manner and further inhibited
HT-1080 cell migration. In addition, naringenin suppressed PMA-enhanced expression of MMP-9
protein, mRNA and transcription activity levels through suppression of nuclear factor κB (NF-
κB) activation and activator protein-1 (AP-1) translocation without changing tissue inhibitor of
metalloproteinase (TIMP)-1 level. Therefore, our results suggested that the inhibitory effects of
naringenin on MMP-9 activation, relation of tumor migration in vitro possibly involve mechanisms
related to its ability to suppress PMA-enhanced MMP-9 gene and protein expression through
NF-κB activation and AP-1 translocation. Overall, naringenin may be a valuable anti-invasive drug
candidate for cancer therapy.
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참고문헌 (17)
참고문헌 신청
Ameer B / 1996 / Flavanone absorption after naringin, hesperidin, and citrus administration / Clin. Pharmacol. Ther. 60 : 34 ~ 40
Cassady JM / 1990 / Natural products as a source of potential cancer chemotherapeutic and chemopreventive agents / J. Nat. Prod. 53 : 23 ~ 41
Chambers AF / 1997 / Changing views of the role of matrix metalloproteinases in metastasis / J. Natl. Cancer Inst. 89 : 1260 ~ 1270
De Clerck YA / 1994 / Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2(TIMP-2) / Gene 139 : 185 ~ 191
Dupuy J / 2003 / Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: Quercetin / Vet. Parasitol. 112 : 337 ~ 347
Cassady JM / 1990 / Natural products as a source of potential cancer chemotherapeutic and chemopreventive agents / J. Nat. Prod. 53 : 23 ~ 41
Chambers AF / 1997 / Changing views of the role of matrix metalloproteinases in metastasis / J. Natl. Cancer Inst. 89 : 1260 ~ 1270
De Clerck YA / 1994 / Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2(TIMP-2) / Gene 139 : 185 ~ 191
Dupuy J / 2003 / Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: Quercetin / Vet. Parasitol. 112 : 337 ~ 347
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