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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 548 - 554 (7page)
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초록· 키워드
오류제보하기
Cordycepin (3'-deoxyadenosine) has been shown to exhibit many pharmacological activities, including anti-cancer, anti-inflammatory, and anti-infection activities.
However, the anti-skin photoaging effects of cordycepinhave not yet been reported. In the present study, we investigated the inhibitory effects of cordycepin on matrix metalloproteinase-1 (MMP-1) and -3 expressions of the human dermal fibroblast cells.
Western blot analysis and real-time PCR revealed cordycepin inhibited UVB-induced MMP-1 and -3 expressions in a dose-dependent manner. UVB strongly activated NF-κB activity, which was determined by IκBα degradation, nuclear localization of p50 and p65 subunit, and NF-κB binding activity. However, UVB-induced NF-κB activation and MMP expression were completely blocked by cordycepin pretreatment.
These findings suggest that cordycepin could preventUVB-induced MMPs expressions through inhibition of NF-κB activation. In conclusion, cordycepin might beused as a potential agent for the prevention and treatment of skin photoaging.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Adhami VM / 2003 / Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol / Neoplasia 5 : 74 ~ 82
Afaq F / 2003 / Suppression of UVB-induced phosphorylation of mitogen-activated protein kinases and nuclear factor kappa B by green tea polyphenol in SKH-1 hairless mice / On
Bell S / 2003 / Involvement of NF-kappaB signalling in skin physiology and disease / Cell Signal 15 : 1 ~ 7
Bond M / 1999 / Nuclear factor kappaB activity is essential for matrix metalloproteinase-1 and -3 upregulation in rabbit dermal fibroblasts / Biochem Biophys Res Commun 264 :
Bradford MM / 1976 / A rapid, sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72 : 248
Afaq F / 2003 / Suppression of UVB-induced phosphorylation of mitogen-activated protein kinases and nuclear factor kappa B by green tea polyphenol in SKH-1 hairless mice / On
Bell S / 2003 / Involvement of NF-kappaB signalling in skin physiology and disease / Cell Signal 15 : 1 ~ 7
Bond M / 1999 / Nuclear factor kappaB activity is essential for matrix metalloproteinase-1 and -3 upregulation in rabbit dermal fibroblasts / Biochem Biophys Res Commun 264 :
Bradford MM / 1976 / A rapid, sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72 : 248
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Effect of Cordycepin Purified from Cordyceps militaris on Th1 and Th2 Cytokines in Mouse Splenocytes
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배지 조성이 번데기 동충하초의 영양성분 및 Cordycepin 함량에 미치는 영향
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Effect of Cordycepin-Enriched Cordyceps militaris Powder on Tissues Lipid Peroxidation and Antioxidative Activity in Orotic Acid-Induced Fatty Liver Model Rats
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2011 .10
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Oral Administration of Lactobacillus plantarum HY7714 Protects Hairless Mouse Against Ultraviolet B-Induced Photoaging
Journal of Microbiology and Biotechnology
2014 .01
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Protective Effects of Portulaca oleracea L. Extract against Matrix Metalloproteinase Production and Reactive Oxygen Species Generation Induced by Ultraviolet B Radiation in Human Keratinocytes
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Improvement Effect of Cordycepin-Enriched Cordyceps militaris JLM 0636 Powder against Orotic Acid-Induced Fatty Liver in Rats
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Low-dose UVB irradiation stimulates matrix metalloproteinase-1 expression via a BLT2-linked pathway in HaCaT cells
Experimental and Molecular Medicine
2010 .01
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Fermented Acanthopanax koreanum Root Extract Reduces UVB- and H2O2-Induced Senescence in Human Skin Fibroblast Cells
Journal of Microbiology and Biotechnology
2016 .01
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