메뉴 건너뛰기
Library Notice
Institutional Access
If you certify, you can access the articles for free.
Check out your institutions.
ex)Hankuk University, Nuri Motors
Log in Register Help KOR
Subject
Humanities
General Humanities History Philosophy Religious Studies Linguistics and Literature Other Humanities
Social science
General Social Science Business Management Tourism Education Military Science Library and Information Science Law Sociology Journalism and Media Studies Psychological Science Political Science and Diplomacy Geography Public Administration Economics International Trade Anthropology Other Social Science
Natural science
General Natural Science Physics Biology Life Sciences Mathematics/Statistics Astronomy Earth Science Chemistry Other Natural Science
Engineering
General Engineering Architectural Engineering Mechanical Engineering Industrial Engineering Material/Energy Engineering Electrical and Electronic Engineering Marine and Ocean Engineering Chemical Engineering Computer Science Other Engineering
Medical science
General Medical Science Nursing Science Veterinary Pharmacy Traditional Korean Medicine Basic Medicine Clinical Medicine Other Medicine
Agriculture and Fishery
General Agriculture and Fishery Agriculture Fishery Science Food Science Forestry Animal Husbandry Marine Transportation Studies Other Agriculture and Fishery
Art and Kinesiology
General Arts Design Fine Arts Cosmetology Photography Music Fashion Kinesiology Performing Media Arts Other Arts and Kinesiology
Interdisciplinary Studies
Interdisciplinary Research Science and Technology Studies Brain and Cognitive Science Technology Policy Other Interdisciplinary Studies

KOR

Regulatory mechanism of Angelica Gigas extract powder on matrix metalloproteinases in vitro and in vivo model
Recommendations
Search
Questions

참당귀 추출분말이 in vitro and in vivo model에서 MMPs 조절 기전

논문 기본 정보

Type
Academic journal
Author
Jin-Hwan Kwon (뉴트라젠) Min-Seok Han (뉴트라젠) Yong-Moon Lee (충북대학교)
Journal
The Korean Society of Analytical Sciences Analytical Science & Technology Vol.28 No.6 KCI Accredited Journals SCOPUS
Published
2015.12
Pages
361 - 369 (9page)

Usage

cover
📌
Topic
📖
Background
🔬
Method
🏆
Result
Regulatory mechanism of Angelica Gigas extract powder on matrix metalloproteinases in vitro and in vivo model
Ask AI
Recommendations
Search
Questions

Abstract· Keywords

Report Errors
The precise mechanism underlying the therapeutic efficacy of an extraction powder of Angelica gigas (AGE) for the treatment of degenerative osteoarthritis was investigated in primary cultured rabbit chondrocytes and in a monosodium-iodoacetate (MIA)-induced osteoarthritis rat model. The treatment with AGE (50 μg/mL) effectively inhibited NF-B activation. The anti-inflammatory mechanism was clarified by gelatin zymography and western blotting measurements of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) activities. The AGE (50 μg/mL) treatment significantly reduced MMP-9 activity. The constituents of AGE—decursinol, decursin, and decursinol angelate—were determined by LC-MS/MS after a 24 hr treatment of rabbit chondrocytes. The contents of the major products, decursin and decursinol angelate, were 3.62±0.47 and 2.14±0.36 μg/mg protein, respectively in AGE-treated (50 μg/mL) rabbit chondrocytes. An in vivo animal study on rats fed a diet containing 25, 50, and 100 mg/kg AGE for 3 weeks revealed a significant inhibition of the MMPs in the MIA-induced rat articular cartilage. The genetic expression of arthritic factors in the articular cartilage was examined by RT-PCR of collagen Type I, collagen Type II, aggrecan, and MMP (MMP3, MMP-9, MMP13). Specifically, AGE up-regulated the expression of collagen Type I, collagen Type II, and aggrecan and inhibited MMP levels at all tested concentrations. Collectively, AGE showed a strong specific site of action on MMP regulation and protected against the degeneration of articular cartilage via cellular regulation of MMP expression both in vitro and in vivo.
#Angelica gigas #osteoarthritis #MMPs #Decursin #Decursinol angelate #ectract

Contents

Abstract
요약
1. 서론
2. 실험재료 및 방법
3. 실험결과 및 고찰
4. 결론
References

References (12)

Add References
[학술지(정기간행물)] - D. Felson / 1988 / / Epidemiol Rev 10 : 1 ~ 28 google schola [학술지(정기간행물)] - V. B. Kraus / 1997 / / Med. Clinics North Am 81 : 85 ~ 112 google schola [학술지(정기간행물)] - J. Martel-Pelletier / 1994 / / Lab Invest 70 : 807 ~ 815 google schola [학술지(정기간행물)] - J. F. Jr, Woessner / 1991 / / J. Rheumatol 27 : 99 ~ 101 google schola [학술지(정기간행물)] - D. D. Dean / 1989 / / J. Clin. Invest 84 : 678 ~ 685 google schola

Recommendations

It is an article recommended by DBpia according to the article similarity. Check out the related articles!

Related Authors

Frequently Viewed Together

사회집단별 감염성질병의 치료효과 차이 : 한국의 메르스(MERS) 사례를 중심으로
김수아 한국사회학회 사회학대회 논문집 2015 .12
Allium hookeri Extract Improves Type 2 Diabetes Mellitus in C57BL/KSJ Db/db Obese Mouse via Regulation of Hepatic Lipogenesis and Glucose Metabolism
Ji-Soo Kim ,  Jin-Sun Heo ,  Jong-Won Choi and others 2 Journal of Life Science 2015 .10
Pharmacokinetic Study of α-Interferon Administered Intravenously and Topically in Experimental Animals
심창구 ,  김대덕 ,  정인환 and others 3 JOURNAL OF BACTERIOLOGY AND VIROLOGY 1985 .06
Effects of coffee powder supplementation on the blood glucose and antioxidative enzyme activity of liver tissue in STZ-induced diabetic rats
Bae ,  Jihyun ,  Jung Journal of Nutrition and Health 2015 .04
Establishment of Distribution System by Individual Packaging of Live Todarodes pacificus
Myung Uk Kim ,  Young Je Cho Journal of the Korean Society of Food Science and Nutrition 2014 .07

Recently viewed articles

일본: 2024년, NHK ‘온라인 수신료’ 도입 전환점 될 듯
안창현Broadcast Research Institute2024.01
 Development of a Metadata Tagging Tool on HTML5 Web Browser for CCTV Video Events
Minji Kang, Minyoung Kang, Jongho NangKorean Institute of Information Scientists and Engineers2020.10
 4차 산업혁명 시대에 미디어 · 콘텐츠 노동 환경의 변화
김동욱The Korean Society Of Broad Engineers2017.07

Comments(0)

0

Write first comments.