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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 401 - 407 (7page)
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초록· 키워드
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Although the apoptosis of chondrocytes plays an important role in endochondral ossification, its mechanism has not been elucidated. In this study, we
show that guanosine induces chondrocyte apop - tosis based on the results of acridine orange/
ethidium bromide staining, caspase-3 activation, and sub-G1 fraction analysis. The potent inhibitory
effect of dipyridamole, a nucleoside transporter blocker, indicates that extracellular guanosine must enter the chondrocytes to induce apoptosis. We
found that guanosine promotes Fas-Fas ligand interaction which, in turn, leads to chondrocyte
apoptosis. These findings indicate a novel mechanism for endochondral ossification via metabolic regulation.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
/ / Autocrine signals enable chon-drocytes to survive in culture : 1069 ~ 77
/ / Long-term culture of capillary endothelial cells : 5217 ~ 21
/ / and inosine nucleotides of chick growth cartilage gua (sine-induced chondrocyte apoptosis 407matsumoto h) : 347 ~ 52
/ 1995 / Administration of growth hormone modulates the gene ex-pression of basic fibroblast growth factor in rat costal cartilage both in vivo and in vitro 112 : 95 ~ 9
/ 1996 / Nucleoside and nucleobase transport systems of mammalian cells 1286 : 153 ~ 81
/ / Long-term culture of capillary endothelial cells : 5217 ~ 21
/ / and inosine nucleotides of chick growth cartilage gua (sine-induced chondrocyte apoptosis 407matsumoto h) : 347 ~ 52
/ 1995 / Administration of growth hormone modulates the gene ex-pression of basic fibroblast growth factor in rat costal cartilage both in vivo and in vitro 112 : 95 ~ 9
/ 1996 / Nucleoside and nucleobase transport systems of mammalian cells 1286 : 153 ~ 81
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