지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 201 - 210 (10page)
이용수
초록· 키워드
오류제보하기
A20 murine lymphoma cells undergoing Fas-medi-ated apoptosis showed increase in the activity ofphospholipase D (PLD), which is involved in prolifera-tive or mitogenic cellular responses. Using A20 celllines that were resistant to Fas-induced apoptosis, weinvestigated the diferential effects of Fas cross-link-ing on PLD activity and sphingolipid metabolism. Thebasal PLD activities in all of the selected three Fas-resistant clones (#5, #8, and #11) were about 2~4 foldshigher than that of wild type A20 cels. Among thePLD isoforms, PLD2 expression was increased in alof the selected Fas-resistant clones. The Fas down-stream signaling events triggered by Fas cross-link-ing, including the activations of PLD, phosphatidy-lcholine-specific phospholipase C (PC-PLC), sphingo-myelinase (SMase), the increase in diacylglycerol(DAG) and protein phosphorylation levels, and thetranslocation of protein kinase C to membrane werenot changed in both of Fas-resistant clone #5 and #8.In contrast, Fas cross-linking stimulated the activity ofPLD, PC-PLC, and SMase, translocation of PKC, andprotein phosphorylation in Fas-resistant clone #11,similar to that of wild type cells. We also found thatclone #1 had a different Fas sequence encoding FasB which has been known to inhibit Fas-induced apo-ptosis. These findings suggest that increased PLD2expression resulting in increased basal PLD activityand the blockade of Fas downstream signaling cas-cades may be involved to limit apoptosis induced byFas cross-linking.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Role of Glycoconjugates in Fas-FasL Interaction and Fas Mediated Apoptosis
한국동물학회 학술대회
1999 .01
-
세포사멸에서 Phospholipase D 동위효소의 기능적 역할
생명과학회지
2014 .12
-
CD43 cross-linking increases the Fas-induced apoptosis through induction of Fas aggregation in Jurkat T-cells
Experimental and Molecular Medicine
2006 .01
-
Anti-apoptotic role of phospholipase D isozymes in the glutamate-induced cell death
Experimental and Molecular Medicine
2003 .01
-
Different role of Gadd45b in TGF-β and Fas-induced apoptosis
한국생명과학회 심포지움
2005 .04
-
FAS를 이용한 서울ㆍ경기지방 호우특성 분석
대기
2003 .04
-
수분함량 변화에 따른 퇴비화 매체에서의 용적밀도와 Free Air Space(FAS) 관계
한국대기환경학회 학술대회논문집
2007 .05
-
Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells
Experimental and Molecular Medicine
2013 .01
-
Role of Gibberellic Acid and Fusaric Acid in Rice Plant Inoculated with Gibberella fujikuroi(Sawada) Ito and Kimura
The Plant Pathology Journal
1989 .06
-
Activation of Phospholipase D2 through Phosphorylation of Tyrosine-470 in Antigen-stimulated Mast Cells
생명과학회지
2005 .06
-
Involvement of protein kinase C pathway in UVC-stimulated phospholipase D2 activity in Vero 76 cells
Experimental and Molecular Medicine
2005 .01
-
Phospholipase D Activity is Elevated in Hepatitis C Virus Core Protein-Transformed NIH 3T3 Mouse Fibroblast Cells
생명과학회지
2003 .10
-
Pathological Roles of Fas Ligand in Non-Lymphoid Tissues
한국미생물학회 학술대회논문집
1998 .04
-
Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells
Experimental and Molecular Medicine
2006 .01
-
피부각질세포 HaCaT에서 진세노사이드 Rb1에 의한 유전자 발현 양상
생명과학회지
2019 .05
-
The Solution Structure of FADD Death Domain: Structural Basis of Death Domain Interactions of Fas and FADD
한국생물물리학회 학술발표회
1999 .01
-
Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells
Experimental and Molecular Medicine
2009 .01
-
Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid
Experimental and Molecular Medicine
2014 .01
-
Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes
Experimental and Molecular Medicine
2011 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0