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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 226 - 232 (7page)
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IL-1β is known promote cycloxygenase-2 (COX- 2) and matrix metaloproteinase-2 (MMP-2) ex-pression. This study focuses on the characteri-IL-1β-induced matrix metaloproteinase-2 (MP- 2) regulation in human chondrocytes. The de-crease in collagen levels in the conditioned media was prevented by a broad spectrum MMP inhibitor, suggesting that IL-1β promotes the proteolytic process leading to MMP-2 activation. IL-1β-related MMP-2 expression was found to be dependent on prostaglandin E2 (PGE2) produc-tion. In adition, the induction of COX-2 and MP-2 was inhibited by the pretreatment of chondrocytes with a SB203580 or Ro 31-8220, indicating the involvement of protein kinase C (PKC) or p38 mitogen-activated protein kinase (MAPK). However, there is no cros-talk bet-ween PKC and p38 MAPK in the IL-1β-induced MP-2 activation. Taken together, these results demonstrated that IL-1β induces MMP-2 expres-sion through the PGE2-dependent mechanism in human chondrocytes.
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참고문헌 (28)
참고문헌 신청
/ / Evidence that responses of articular chondrocytes to interleukin-1 and basic fibroblast growth factor are not mediated by protein kinase C : 157 ~ 62
/ / Interleukin 1 and phorbol 12-myristate 13-acetate induce colagenase and PGE2 production through a PKC-independent mechanism in chondrocytes : 1 ~ 6
/ 191-9 / Influence of interleukin-1β tumour necrosis factor-α and prostaglandin E2 on chondrogenesis and cartilage matrix breakdown in vitro
/ 1995 / Cyclooxygenase inhi-bitors augment the production of pro-matrix metaloproteinase 9 : 75 ~ 9
/ 1995 / Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes : 796 ~ 801
/ / Interleukin 1 and phorbol 12-myristate 13-acetate induce colagenase and PGE2 production through a PKC-independent mechanism in chondrocytes : 1 ~ 6
/ 191-9 / Influence of interleukin-1β tumour necrosis factor-α and prostaglandin E2 on chondrogenesis and cartilage matrix breakdown in vitro
/ 1995 / Cyclooxygenase inhi-bitors augment the production of pro-matrix metaloproteinase 9 : 75 ~ 9
/ 1995 / Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes : 796 ~ 801
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