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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 453 - 460 (8page)
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초록· 키워드
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βig-h3 is a TGF-β-induced extracellular matrix protein
which is expressed in many tissues including bones
and cartilages. In previous reports, we showed that
βig-h3 mediates cell adhesion and migration and, especially
in bones, negatively regulates the mineralization
in the end stage of endochondral ossification.
Here, to elucidate the expression pattern and role of
βig-h3 in chondrocyte differentiation, ATDC5 chondrocytes
and embryonic and postnatal mice were used
for in vitro differentiation studies and in vivo studies,
respectively. βig-h3 was strongly induced by the treatment
of TGF-β1 and the expression level of βig-h3
mRNA and protein were highly expressed in the early
stages of differentiation but decreased in the late
stages in ATDC5. Furthermore, the patterns of TGF-β1,
-β2, and -β3 mRNA expression were concurrent with
βig-h3 in ATDC5. βig-h3 was deeply stained in perichondrium
(PC), periosteum (PO), and prehypertrophic
chondrocytes (PH) through the entire period of endochondral
ossification in mice. βig-h3 was mainly expressed
in PC and PH at embryonic days and obviously
in PH in postnatal days. These results suggest that
βig-h3 may play a critical role as a regulator of chondrogenic
differentiation in endochondral ossification.
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참고문헌 (22)
참고문헌 신청
Akiyama H / 1997 / Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal m
Chen Q / 1995 / Progression and recapitulation of the chondrocyte differentiation program: cartilage matrix protein is a marker for cartilage maturation / Dev Biol 172 : 293
Ferguson JW / 2003 / Developmental expression patterns of Beta-ig (betaIG-H3) and its function as a cell adhesion protein / Mech Dev 120 : 851 ~ 64
Gibson G / 2001 / The release and activation of transforming growth factor beta2 associated with apoptosis of chick hypertrophic chondrocytes / J Bone Miner Res 16 : 2330 ~ 8
Goetinck PF / 1991 / Proteoglycans in development / Curr Top Dev 7Biol 25 : 111 ~ 31
Chen Q / 1995 / Progression and recapitulation of the chondrocyte differentiation program: cartilage matrix protein is a marker for cartilage maturation / Dev Biol 172 : 293
Ferguson JW / 2003 / Developmental expression patterns of Beta-ig (betaIG-H3) and its function as a cell adhesion protein / Mech Dev 120 : 851 ~ 64
Gibson G / 2001 / The release and activation of transforming growth factor beta2 associated with apoptosis of chick hypertrophic chondrocytes / J Bone Miner Res 16 : 2330 ~ 8
Goetinck PF / 1991 / Proteoglycans in development / Curr Top Dev 7Biol 25 : 111 ~ 31
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